TY - JOUR
T1 - Selected Topics in the Molecular Pathology of Endometrial Carcinoma
AU - Djordjevic, Bojana
AU - Broaddus, Russell R.
N1 - Funding Information:
This work was supported by NIH 1P50CA098258-01 (SPORE in Uterine Cancer).
PY - 2011/3
Y1 - 2011/3
N2 - In the developed world, endometrial carcinoma is the most common malignant tumor of the female gynecologic tract. Numerous epidemiologic studies indicate that exposure to unopposed estrogen is a significant risk factor for developing endometrial cancer, particularly endometrioid-type endometrial carcinoma; however, a number of other molecular pathways and mechanisms are also important in endometrial cancer. In this review, the authors highlight some of the more interesting molecular pathways in endometrial cancer, such as the PTEN/PI3K/AKT pathway, microsatellite instability, and molecular mediators of epithelial-to-mesenchymal transition.
AB - In the developed world, endometrial carcinoma is the most common malignant tumor of the female gynecologic tract. Numerous epidemiologic studies indicate that exposure to unopposed estrogen is a significant risk factor for developing endometrial cancer, particularly endometrioid-type endometrial carcinoma; however, a number of other molecular pathways and mechanisms are also important in endometrial cancer. In this review, the authors highlight some of the more interesting molecular pathways in endometrial cancer, such as the PTEN/PI3K/AKT pathway, microsatellite instability, and molecular mediators of epithelial-to-mesenchymal transition.
KW - Endometrial cancer
KW - Epithelial-to-mesenchymal transition
KW - Estrogen
KW - Microsatellite instability
KW - PTEN
UR - http://www.scopus.com/inward/record.url?scp=79951776203&partnerID=8YFLogxK
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U2 - 10.1016/j.path.2010.12.001
DO - 10.1016/j.path.2010.12.001
M3 - Review article
C2 - 26837291
AN - SCOPUS:79951776203
SN - 1875-9181
VL - 4
SP - 131
EP - 147
JO - Surgical Pathology Clinics
JF - Surgical Pathology Clinics
IS - 1
ER -