TY - JOUR
T1 - Selection and Prejudice
T2 - Addressing Clinical Trial Disparities With a Review of Current Shortcomings and Future Directions
AU - Corrigan, Kelsey L.
AU - Rooney, Michael K.
AU - Kouzy, Ramez
AU - Manzar, Gohar
AU - Thomas, Charles R.
AU - Ludmir, Ethan B.
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/10
Y1 - 2023/10
N2 - Growing evidence has demonstrated significant, persistent, and widespread disparities in cancer clinical trial enrollment across myriad disease sites and target populations. Although mechanisms underlying such disparities are complex and multifactorial, clinical trial eligibility criteria may serve as a key structural barrier to equitable and diverse trial enrollment. In this review, we provide an overview of the data describing historical and current disparities in cancer clinical trial enrollment and subsequently describe several patient-, institution-, and trial-related factors which appear to be key drivers of enrollment inequity, with specific discussion regarding the impact of eligibility criteria. We further describe the landscape of ongoing professional efforts aimed at eliminating clinical trial disparities through various medical, professional, and advocacy groups. The review concludes with a practical discussion of how modernization of eligibility criteria in clinical trials may decrease or eliminate trial disparities, including specific actionable recommendations aimed at improving the quality of future eligibility criteria.
AB - Growing evidence has demonstrated significant, persistent, and widespread disparities in cancer clinical trial enrollment across myriad disease sites and target populations. Although mechanisms underlying such disparities are complex and multifactorial, clinical trial eligibility criteria may serve as a key structural barrier to equitable and diverse trial enrollment. In this review, we provide an overview of the data describing historical and current disparities in cancer clinical trial enrollment and subsequently describe several patient-, institution-, and trial-related factors which appear to be key drivers of enrollment inequity, with specific discussion regarding the impact of eligibility criteria. We further describe the landscape of ongoing professional efforts aimed at eliminating clinical trial disparities through various medical, professional, and advocacy groups. The review concludes with a practical discussion of how modernization of eligibility criteria in clinical trials may decrease or eliminate trial disparities, including specific actionable recommendations aimed at improving the quality of future eligibility criteria.
UR - http://www.scopus.com/inward/record.url?scp=85167449791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85167449791&partnerID=8YFLogxK
U2 - 10.1016/j.semradonc.2023.06.002
DO - 10.1016/j.semradonc.2023.06.002
M3 - Review article
C2 - 37684066
AN - SCOPUS:85167449791
SN - 1053-4296
VL - 33
SP - 367
EP - 373
JO - Seminars in radiation oncology
JF - Seminars in radiation oncology
IS - 4
ER -