TY - JOUR
T1 - Selective hyperpolarization of heteronuclear singlet states via pulsed microtesla SABRE
AU - Tanner, Christian P.N.
AU - Lindale, Jacob R.
AU - Eriksson, Shannon L.
AU - Zhou, Zijian
AU - Colell, Johannes F.P.
AU - Theis, Thomas
AU - Warren, Warren S.
N1 - Publisher Copyright:
© 2019 Author(s).
PY - 2019/7/28
Y1 - 2019/7/28
N2 - Signal Amplification By Reversible Exchange (SABRE) and its heteronuclear variant SABRE in SHield Enables Alignment Transfer to Heteronuclei create large nuclear magnetization in target ligands, exploiting level crossings in an iridium catalyst that transiently binds both the ligands and parahydrogen. This requires a specific, small magnetic field to match Zeeman splittings to scalar couplings. Here, we explore a different strategy, direct creation of heteronuclear singlet states in the target ligands, which produces enhanced signals at other field strengths, including zero field. We also show that pulsed methods (including pulsed field nulling) coherently and selectively pump such singlets, affording a significant enhancement on the resulting hyperpolarization.
AB - Signal Amplification By Reversible Exchange (SABRE) and its heteronuclear variant SABRE in SHield Enables Alignment Transfer to Heteronuclei create large nuclear magnetization in target ligands, exploiting level crossings in an iridium catalyst that transiently binds both the ligands and parahydrogen. This requires a specific, small magnetic field to match Zeeman splittings to scalar couplings. Here, we explore a different strategy, direct creation of heteronuclear singlet states in the target ligands, which produces enhanced signals at other field strengths, including zero field. We also show that pulsed methods (including pulsed field nulling) coherently and selectively pump such singlets, affording a significant enhancement on the resulting hyperpolarization.
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U2 - 10.1063/1.5108644
DO - 10.1063/1.5108644
M3 - Article
C2 - 31370556
AN - SCOPUS:85069782498
SN - 0021-9606
VL - 151
JO - Journal of Chemical Physics
JF - Journal of Chemical Physics
IS - 4
M1 - 044201
ER -