Abstract
Estrogen-stimulated cell proliferation is thought to be mediated by the induction of growth-regulatory factors. Abnormal regulation of such factors may be associated with tumorigenesis. Two such factors, vascular endothelial growth factor and c-fos, are rapidly induced in the uterus by estrogens. We show that the induction of these transcripts by 17β-estradiol or tamoxifen is selectively blocked by the pure antiestrogen ICI 182,780 in a dose- dependent manner. This indicates that induction of the two genes requires different levels of estrogen receptor or that their induction occurs by different mechanisms. This suggests that selective dose-dependent antagonism of estrogen-dependent transcription may be possible in target tissues and tumors.
Original language | English (US) |
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Pages (from-to) | 2547-2549 |
Number of pages | 3 |
Journal | Cancer Research |
Volume | 57 |
Issue number | 13 |
State | Published - Jul 1 1997 |
ASJC Scopus subject areas
- Oncology
- Cancer Research