Selenoproteins and epigenetic regulation in mammals

Hsin Yi Lu; Berna Somuncu; Jianhong Zhu; Meltem Muftuoglu; Wen Hsing Cheng

doi:10.1007/978-3-319-55530-0_31

Selenoproteins and epigenetic regulation in mammals

Hsin Yi Lu, Berna Somuncu, Jianhong Zhu, Meltem Muftuoglu, Wen Hsing Cheng

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Selenium is an essential mineral. There is a total of 25 mammalian selenoproteins that confer the majority of physiological and pathophysiological functions of selenium. All functionally characterized selenoproteins are oxidoreductases. In humans, extremely low levels of selenium in the body result in classic selenium deficiency diseases, and patients with mutations in genes involved in selenoprotein expression show selenoprotein deficiency and multisystem defects. Recent progress suggests important roles of certain selenoproteins in epigenetic regulation of promoter methylation, histone modifications, noncoding RNA expressions, and genome stability. Conversely, such epigenetic events can also influence selenoprotein expression. Understanding how selenoproteins function in epigenetic regulations will continue to offer positive impact on selenium regulation toward optimal health.

Original language	English (US)
Title of host publication	Handbook of Nutrition, Diet, and Epigenetics
Publisher	Springer International Publishing
Pages	1803-1817
Number of pages	15
Volume	3
ISBN (Electronic)	9783319555300
ISBN (Print)	9783319555294
DOIs	https://doi.org/10.1007/978-3-319-55530-0_31
State	Published - Jan 5 2019
Externally published	Yes

Keywords

CpG methylation
Genome maintenance
Histone
Mineral
Noncoding RNA
Nutrition
Oxidative stress
Selenium
Selenocysteine
Selenoproteins

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1007/978-3-319-55530-0_31

Cite this

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title = "Selenoproteins and epigenetic regulation in mammals",

abstract = "Selenium is an essential mineral. There is a total of 25 mammalian selenoproteins that confer the majority of physiological and pathophysiological functions of selenium. All functionally characterized selenoproteins are oxidoreductases. In humans, extremely low levels of selenium in the body result in classic selenium deficiency diseases, and patients with mutations in genes involved in selenoprotein expression show selenoprotein deficiency and multisystem defects. Recent progress suggests important roles of certain selenoproteins in epigenetic regulation of promoter methylation, histone modifications, noncoding RNA expressions, and genome stability. Conversely, such epigenetic events can also influence selenoprotein expression. Understanding how selenoproteins function in epigenetic regulations will continue to offer positive impact on selenium regulation toward optimal health.",

keywords = "CpG methylation, Genome maintenance, Histone, Mineral, Noncoding RNA, Nutrition, Oxidative stress, Selenium, Selenocysteine, Selenoproteins",

author = "Lu, {Hsin Yi} and Berna Somuncu and Jianhong Zhu and Meltem Muftuoglu and Cheng, {Wen Hsing}",

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T1 - Selenoproteins and epigenetic regulation in mammals

AU - Lu, Hsin Yi

AU - Somuncu, Berna

AU - Zhu, Jianhong

AU - Muftuoglu, Meltem

AU - Cheng, Wen Hsing

PY - 2019/1/5

Y1 - 2019/1/5

N2 - Selenium is an essential mineral. There is a total of 25 mammalian selenoproteins that confer the majority of physiological and pathophysiological functions of selenium. All functionally characterized selenoproteins are oxidoreductases. In humans, extremely low levels of selenium in the body result in classic selenium deficiency diseases, and patients with mutations in genes involved in selenoprotein expression show selenoprotein deficiency and multisystem defects. Recent progress suggests important roles of certain selenoproteins in epigenetic regulation of promoter methylation, histone modifications, noncoding RNA expressions, and genome stability. Conversely, such epigenetic events can also influence selenoprotein expression. Understanding how selenoproteins function in epigenetic regulations will continue to offer positive impact on selenium regulation toward optimal health.

AB - Selenium is an essential mineral. There is a total of 25 mammalian selenoproteins that confer the majority of physiological and pathophysiological functions of selenium. All functionally characterized selenoproteins are oxidoreductases. In humans, extremely low levels of selenium in the body result in classic selenium deficiency diseases, and patients with mutations in genes involved in selenoprotein expression show selenoprotein deficiency and multisystem defects. Recent progress suggests important roles of certain selenoproteins in epigenetic regulation of promoter methylation, histone modifications, noncoding RNA expressions, and genome stability. Conversely, such epigenetic events can also influence selenoprotein expression. Understanding how selenoproteins function in epigenetic regulations will continue to offer positive impact on selenium regulation toward optimal health.

KW - CpG methylation

KW - Genome maintenance

KW - Histone

KW - Mineral

KW - Noncoding RNA

KW - Nutrition

KW - Oxidative stress

KW - Selenium

KW - Selenocysteine

KW - Selenoproteins

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BT - Handbook of Nutrition, Diet, and Epigenetics

PB - Springer International Publishing

ER -

Selenoproteins and epigenetic regulation in mammals

Abstract

Keywords

ASJC Scopus subject areas

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