TY - JOUR
T1 - Self-reported oral morbidities in long-term oropharyngeal cancer survivors
T2 - A cross-sectional survey of 906 survivors
AU - MD Anderson Head and Neck Cancer Symptom Working Group
AU - Cardoso, Richard C.
AU - Qazali, Ahmad
AU - Zaveri, Jhankruti
AU - Chambers, Mark S.
AU - Gunn, Gary Brandon
AU - Fuller, Clifton D.
AU - Lai, Stephen Y.
AU - Mott, Frank E.
AU - Hutcheson, Katherine A.
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/9
Y1 - 2018/9
N2 - Objective: The purpose of this study is to estimate the prevalence and severity of late oral morbidities in disease-free oropharyngeal cancer (OPC) survivors using patient reported outcomes. Materials and methods: Cross-sectional survivorship survey of patients who completed definitive treatment for oropharyngeal carcinoma > 12-months previously without evidence of recurrence, second primary malignancy, or distant metastasis after index cancer. Using MD Anderson Symptom Inventory- Head and Neck Module (MDASI-HN), scores for 4 self-reported oral morbidities: dry mouth, mucus secretions, mouth and throat sores, and teeth and gum issues were evaluated. Results: Among 906 survey respondents (57% response rate), (median survival time: 7 years), “dry mouth” and “problems with my mucus” were reported moderate/severe (MDASI-HN item score ≥5) in 39% and 22% of respondents, while 14% reported moderate/severe “problems with teeth and gums”. Smoking at the time of survey was significantly associated with the severity of oral symptoms including “mucus” (p = 0.03), “dry mouth” (p = 0.02), “problems with my teeth and gums” (p = 0.001). All the oral morbidities symptom items significantly, positively correlated with the mean interference scores reflecting adverse impact to quality of life (QOL): “mucus” (r = 0.445, p < 0.001), “problems with teeth” (r = 0.446, p < 0.001), “mouth sores” (r = 0.321, p < 0.001) and “dry mouth” (r = 0.459, p < 0.001). Conclusion: This study showed that 45.5% reported at least one late oral morbidity at moderate/severe level which negatively correlated overall function, even years after treatment.
AB - Objective: The purpose of this study is to estimate the prevalence and severity of late oral morbidities in disease-free oropharyngeal cancer (OPC) survivors using patient reported outcomes. Materials and methods: Cross-sectional survivorship survey of patients who completed definitive treatment for oropharyngeal carcinoma > 12-months previously without evidence of recurrence, second primary malignancy, or distant metastasis after index cancer. Using MD Anderson Symptom Inventory- Head and Neck Module (MDASI-HN), scores for 4 self-reported oral morbidities: dry mouth, mucus secretions, mouth and throat sores, and teeth and gum issues were evaluated. Results: Among 906 survey respondents (57% response rate), (median survival time: 7 years), “dry mouth” and “problems with my mucus” were reported moderate/severe (MDASI-HN item score ≥5) in 39% and 22% of respondents, while 14% reported moderate/severe “problems with teeth and gums”. Smoking at the time of survey was significantly associated with the severity of oral symptoms including “mucus” (p = 0.03), “dry mouth” (p = 0.02), “problems with my teeth and gums” (p = 0.001). All the oral morbidities symptom items significantly, positively correlated with the mean interference scores reflecting adverse impact to quality of life (QOL): “mucus” (r = 0.445, p < 0.001), “problems with teeth” (r = 0.446, p < 0.001), “mouth sores” (r = 0.321, p < 0.001) and “dry mouth” (r = 0.459, p < 0.001). Conclusion: This study showed that 45.5% reported at least one late oral morbidity at moderate/severe level which negatively correlated overall function, even years after treatment.
KW - Dry mouth
KW - Mouth sores
KW - Oral morbidities
KW - Oropharyngeal carcinoma
KW - Patient-reported outcomes
KW - Xerostomia
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U2 - 10.1016/j.oraloncology.2018.07.006
DO - 10.1016/j.oraloncology.2018.07.006
M3 - Article
C2 - 30115482
AN - SCOPUS:85050402034
SN - 1368-8375
VL - 84
SP - 88
EP - 94
JO - Oral Oncology
JF - Oral Oncology
ER -