Abstract
CD8+ T cells eliminate intracellular infections through two contact-dependent effector functions: cytolysis and secretion of antiviral cytokines. Here we identify the following additional function for memory CD8+ T cells that persist at front-line sites of microbial exposure: to serve as local sensors of previously encountered antigens that precipitate innate-like alarm signals and draw circulating memory CD8+ T cells into the tissue. When memory CD8+ T cells residing in the female mouse reproductive tract encountered cognate antigen, they expressed interferon-γ (IFN-γ), potentiated robust local expression of inflammatory chemokines and induced rapid recruitment of circulating memory CD8+ T cells. Anamnestic responses in front-line tissues are thus an integrated collaboration between front-line and circulating populations of memory CD8+ T cells, and vaccines should establish both populations to maximize rapid responses.
Original language | English (US) |
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Pages (from-to) | 509-513 |
Number of pages | 5 |
Journal | Nature Immunology |
Volume | 14 |
Issue number | 5 |
DOIs | |
State | Published - May 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology