TY - JOUR
T1 - Septa design study for volumetric imaging in positron emission tomography
AU - Aykac, Mehmet
AU - Uribe, Jorge
AU - Baghaei, Hossain
AU - Li, Hongdi
AU - Wang, Yu
AU - Liu, Yaqiang
AU - Xing, Tao
AU - Wong, Wai Hoi
N1 - Funding Information:
Manuscript received November 20, 2001. This work was supported by NIH Grants RO1 CA76246, RO1 CA61880, and RO1 CA58980, the J. S. Dunn Research Foundation, and the Cobb Endowment for Cancer Research.
PY - 2002/10
Y1 - 2002/10
N2 - Positron emission tomography (PET) has become an essential imaging tool to localize tumors in diagnostic radiology and to monitor the size of a lesion before and during the treatment in oncology. Currently, commercial PET cameras operate only in two extreme modes: i) no-septa: three-dimensional (3-D) acquisition mode, also called volumetric imaging; and ii) all-septa-in: two-dimensional (2-D) acquisition mode, also called multislice imaging. In this paper, intermediate septa designs in the brain mode have been sought to minimize the scatter and accidental coincidences with acceptable sensitivity loss. To achieve this goal, Monte Carlo simulations were performed to evaluate possible septa designs. Information about septal penetration, absorption and scattering components from simulations guided us to modify the thickness and total number of septa in the new configurations. Count rate performances of three septa configurations were measured on our experimental high resolution PET camera with 3.85-cm axial field-of-view (AFOV); the measurements were compared with the simulation results. No-septa configuration had lower noise equivalent count (NEC) compared the other two configurations because of small AFOV. Monte Carlo simulations were performed to predict the count rate performances of seven septa configurations for 13.1-cm AFOV. In the large AFOV, because of increased number of line of responses, NEC rate for no-septa case peaked rapidly at 0.07 μCi/cc. No-septa configuration is not recommended for high count rate studies. In this case where activity density is 0.3 μCi/cc or more, 10-septa and 15-septa configurations performed better than the other configurations. Intermediate 5-septa designs with variable septum length performed better between 0.07-μCi/cc and 0.3-μCi/cc range which represents the clinical activity level for 18F-FDG brain studies.
AB - Positron emission tomography (PET) has become an essential imaging tool to localize tumors in diagnostic radiology and to monitor the size of a lesion before and during the treatment in oncology. Currently, commercial PET cameras operate only in two extreme modes: i) no-septa: three-dimensional (3-D) acquisition mode, also called volumetric imaging; and ii) all-septa-in: two-dimensional (2-D) acquisition mode, also called multislice imaging. In this paper, intermediate septa designs in the brain mode have been sought to minimize the scatter and accidental coincidences with acceptable sensitivity loss. To achieve this goal, Monte Carlo simulations were performed to evaluate possible septa designs. Information about septal penetration, absorption and scattering components from simulations guided us to modify the thickness and total number of septa in the new configurations. Count rate performances of three septa configurations were measured on our experimental high resolution PET camera with 3.85-cm axial field-of-view (AFOV); the measurements were compared with the simulation results. No-septa configuration had lower noise equivalent count (NEC) compared the other two configurations because of small AFOV. Monte Carlo simulations were performed to predict the count rate performances of seven septa configurations for 13.1-cm AFOV. In the large AFOV, because of increased number of line of responses, NEC rate for no-septa case peaked rapidly at 0.07 μCi/cc. No-septa configuration is not recommended for high count rate studies. In this case where activity density is 0.3 μCi/cc or more, 10-septa and 15-septa configurations performed better than the other configurations. Intermediate 5-septa designs with variable septum length performed better between 0.07-μCi/cc and 0.3-μCi/cc range which represents the clinical activity level for 18F-FDG brain studies.
KW - Deadtime model
KW - Monte Carlo simulation
KW - Noise equivalent curve
KW - Positron emission tomography (PET)
KW - Scatter fraction
KW - Septa
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U2 - 10.1109/TNS.2002.803812
DO - 10.1109/TNS.2002.803812
M3 - Article
AN - SCOPUS:0036816445
SN - 0018-9499
VL - 49 I
SP - 2097
EP - 2102
JO - IEEE Transactions on Nuclear Science
JF - IEEE Transactions on Nuclear Science
IS - 5
ER -