Sequence of the mouse XPC cDNA and genomic structure of the human XPC gene

Lei Li; Carolyn Peterson; Randy Legerski

doi:10.1093/nar/24.6.1026

Sequence of the mouse XPC cDNA and genomic structure of the human XPC gene

Lei Li, Carolyn Peterson, Randy Legerski

Genetics

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The full length-mouse XPC cDNA contains a 2703 bp orf which encodes a polypeptide containing 900 amino acids. Overall, there is 75% identity in nucleotide sequence and 73% identity in amino acid sequence between mouse and human genes. The C-terminal half is more conserved (80%) than the N-terminal half (65%). Northern analysis has revealed a constitutive expression pattern for both human and mouse transcripts in various tissues examined. However, high level expression was observed in liver, testis and kidney in both species. The human XPC gene was cloned from a cosmid library and the full-length gene was found to span ~ 24 kb. Analysis of the genomic structure indicated that the transcribed sequence is divided into 15 exons.

Original language	English (US)
Pages (from-to)	1026-1028
Number of pages	3
Journal	Nucleic acids research
Volume	24
Issue number	6
DOIs	https://doi.org/10.1093/nar/24.6.1026
State	Published - 1996

ASJC Scopus subject areas

Genetics

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10.1093/nar/24.6.1026

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title = "Sequence of the mouse XPC cDNA and genomic structure of the human XPC gene",

abstract = "The full length-mouse XPC cDNA contains a 2703 bp orf which encodes a polypeptide containing 900 amino acids. Overall, there is 75% identity in nucleotide sequence and 73% identity in amino acid sequence between mouse and human genes. The C-terminal half is more conserved (80%) than the N-terminal half (65%). Northern analysis has revealed a constitutive expression pattern for both human and mouse transcripts in various tissues examined. However, high level expression was observed in liver, testis and kidney in both species. The human XPC gene was cloned from a cosmid library and the full-length gene was found to span ~ 24 kb. Analysis of the genomic structure indicated that the transcribed sequence is divided into 15 exons.",

author = "Lei Li and Carolyn Peterson and Randy Legerski",

note = "Funding Information: Craig Chinault for his assistance in isolating XPC YAC clones. The DNA sequencing was performed in the MDACC core facility supported by grant CA16672 from the US National Cancer Institute (NCI). This work was supported by grant CA52461 from NCI.",

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AU - Peterson, Carolyn

AU - Legerski, Randy

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Sequence of the mouse XPC cDNA and genomic structure of the human XPC gene

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