Sequential exposure of Aspergillus fumigatus to itraconazole and caspofungin: Evidence of enhanced in vitro activity

Dimitrios P. Kontoyiannis; Russell E. Lewis; Michail S. Lionakis; Nathaniel D. Albert; Gregory S. May; Issam I. Raad

doi:10.1016/S0732-8893(03)00136-6

Sequential exposure of Aspergillus fumigatus to itraconazole and caspofungin: Evidence of enhanced in vitro activity

Dimitrios P. Kontoyiannis, Russell E. Lewis, Michail S. Lionakis, Nathaniel D. Albert, Gregory S. May, Issam I. Raad

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We investigated the in vitro activity of sequential itraconazole and caspofungin against 10 isolates of Aspergillus fumigatus. Previous exposure of A. fumigatus to itraconazole resulted in dose-dependent enhanced effects of caspofungin and vice versa. Our finding suggests a preferential role for azole-caspofungin sequential combinations and merits further in vivo investigation.

Original language	English (US)
Pages (from-to)	415-419
Number of pages	5
Journal	Diagnostic Microbiology and Infectious Disease
Volume	47
Issue number	2
DOIs	https://doi.org/10.1016/S0732-8893(03)00136-6
State	Published - Oct 2003

Keywords

A. fumigatus
Caspofungin;
Itraconazole;

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/S0732-8893(03)00136-6

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title = "Sequential exposure of Aspergillus fumigatus to itraconazole and caspofungin: Evidence of enhanced in vitro activity",

abstract = "We investigated the in vitro activity of sequential itraconazole and caspofungin against 10 isolates of Aspergillus fumigatus. Previous exposure of A. fumigatus to itraconazole resulted in dose-dependent enhanced effects of caspofungin and vice versa. Our finding suggests a preferential role for azole-caspofungin sequential combinations and merits further in vivo investigation.",

keywords = "A. fumigatus, Caspofungin;, Itraconazole;",

author = "Kontoyiannis, {Dimitrios P.} and Lewis, {Russell E.} and Lionakis, {Michail S.} and Albert, {Nathaniel D.} and May, {Gregory S.} and Raad, {Issam I.}",

year = "2003",

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language = "English (US)",

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T1 - Sequential exposure of Aspergillus fumigatus to itraconazole and caspofungin

T2 - Evidence of enhanced in vitro activity

AU - Kontoyiannis, Dimitrios P.

AU - Lewis, Russell E.

AU - Lionakis, Michail S.

AU - Albert, Nathaniel D.

AU - May, Gregory S.

AU - Raad, Issam I.

PY - 2003/10

Y1 - 2003/10

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AB - We investigated the in vitro activity of sequential itraconazole and caspofungin against 10 isolates of Aspergillus fumigatus. Previous exposure of A. fumigatus to itraconazole resulted in dose-dependent enhanced effects of caspofungin and vice versa. Our finding suggests a preferential role for azole-caspofungin sequential combinations and merits further in vivo investigation.

KW - A. fumigatus

KW - Caspofungin;

KW - Itraconazole;

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SN - 0732-8893

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JO - Diagnostic Microbiology and Infectious Disease

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IS - 2

ER -

Sequential exposure of Aspergillus fumigatus to itraconazole and caspofungin: Evidence of enhanced in vitro activity

Abstract

Keywords

ASJC Scopus subject areas

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