Sequential high-dose cytosine arabinoside-asparaginase treatment in advanced childhood leukemia

R. J. Wells; J. Feusner; R. Devney; W. G. Woods; A. J. Provisor; M. S. Cairo; L. F. Odom; J. Nachman; G. R. Jones; L. J. Ettinger

doi:10.1200/JCO.1985.3.7.998

Sequential high-dose cytosine arabinoside-asparaginase treatment in advanced childhood leukemia

R. J. Wells, J. Feusner, R. Devney, W. G. Woods, A. J. Provisor, M. S. Cairo, L. F. Odom, J. Nachman, G. R. Jones, L. J. Ettinger

Pediatrics

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50 Scopus citations

Abstract

Sequential high-dose cytosine arabinoside (ara-C) and asparaginase were given to 41 children age 6 months to 21 years of age with advanced leukemia. Ten of 22 patients with acute lymphocytic leukemia (ALL) and 8 of 19 patients with acute nonlymphocytic leukemia (ANLL) obtained complete remissions. The most significant toxicity seen was infection in 22 patients. In addition, patients given intrathecal chemotherapy within 24 hours of ara-C developed neurologic toxicity. The high response rate seen in these patients with advanced leukemia indicates that a trial of this regimen is warranted in children with less advanced ALL and ANLL.

Original language	English (US)
Pages (from-to)	998-1004
Number of pages	7
Journal	Journal of Clinical Oncology
Volume	3
Issue number	7
DOIs	https://doi.org/10.1200/JCO.1985.3.7.998
State	Published - 1985

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1200/JCO.1985.3.7.998

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title = "Sequential high-dose cytosine arabinoside-asparaginase treatment in advanced childhood leukemia",

abstract = "Sequential high-dose cytosine arabinoside (ara-C) and asparaginase were given to 41 children age 6 months to 21 years of age with advanced leukemia. Ten of 22 patients with acute lymphocytic leukemia (ALL) and 8 of 19 patients with acute nonlymphocytic leukemia (ANLL) obtained complete remissions. The most significant toxicity seen was infection in 22 patients. In addition, patients given intrathecal chemotherapy within 24 hours of ara-C developed neurologic toxicity. The high response rate seen in these patients with advanced leukemia indicates that a trial of this regimen is warranted in children with less advanced ALL and ANLL.",

author = "Wells, {R. J.} and J. Feusner and R. Devney and Woods, {W. G.} and Provisor, {A. J.} and Cairo, {M. S.} and Odom, {L. F.} and J. Nachman and Jones, {G. R.} and Ettinger, {L. J.}",

year = "1985",

doi = "10.1200/JCO.1985.3.7.998",

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T1 - Sequential high-dose cytosine arabinoside-asparaginase treatment in advanced childhood leukemia

AU - Wells, R. J.

AU - Feusner, J.

AU - Devney, R.

AU - Woods, W. G.

AU - Provisor, A. J.

AU - Cairo, M. S.

AU - Odom, L. F.

AU - Nachman, J.

AU - Jones, G. R.

AU - Ettinger, L. J.

PY - 1985

Y1 - 1985

N2 - Sequential high-dose cytosine arabinoside (ara-C) and asparaginase were given to 41 children age 6 months to 21 years of age with advanced leukemia. Ten of 22 patients with acute lymphocytic leukemia (ALL) and 8 of 19 patients with acute nonlymphocytic leukemia (ANLL) obtained complete remissions. The most significant toxicity seen was infection in 22 patients. In addition, patients given intrathecal chemotherapy within 24 hours of ara-C developed neurologic toxicity. The high response rate seen in these patients with advanced leukemia indicates that a trial of this regimen is warranted in children with less advanced ALL and ANLL.

AB - Sequential high-dose cytosine arabinoside (ara-C) and asparaginase were given to 41 children age 6 months to 21 years of age with advanced leukemia. Ten of 22 patients with acute lymphocytic leukemia (ALL) and 8 of 19 patients with acute nonlymphocytic leukemia (ANLL) obtained complete remissions. The most significant toxicity seen was infection in 22 patients. In addition, patients given intrathecal chemotherapy within 24 hours of ara-C developed neurologic toxicity. The high response rate seen in these patients with advanced leukemia indicates that a trial of this regimen is warranted in children with less advanced ALL and ANLL.

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Sequential high-dose cytosine arabinoside-asparaginase treatment in advanced childhood leukemia

Abstract

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