Abstract
Thirty-three patients with metastatic colorectal carcinoma were treated with sequential conventional dose methotrexate (60 mg/m2) followed within 1 hour by 5-fluorouracil (1000 mg/m2) every 3 weeks. Thirty of 33 patients were assessable for response. One patient (3%) achieved a partial remission (3.5 months). Three patients demonstrated minor tumor regressions. In an additional 17 patients, tumor stabilization was observed. The treatments were tolerated without any significant morbidity. A disappointingly low response rate was observed in our study as opposed to previous reports. Further clinical studies are necessary to establish the optimum dose levels and scheduling of sequential methotrexate and 5-fluorouracil.
Original language | English (US) |
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Pages (from-to) | 69-71 |
Number of pages | 3 |
Journal | American Journal of Clinical Oncology: Cancer Clinical Trials |
Volume | 8 |
Issue number | 1 |
DOIs | |
State | Published - 1985 |
ASJC Scopus subject areas
- Oncology
- Cancer Research