Abstract
Background: Serum ferritin was discovered in the 1930s, and was developed as a clinical test in the 1970s. Many diseases are associated with iron overload or iron deficiency. Serum ferritin is widely used in diagnosing and monitoring these diseases. Scope of review: In this chapter, we discuss the role of serum ferritin in physiological and pathological processes and its use as a clinical tool. Major conclusions: Although many aspects of the fundamental biology of serum ferritin remain surprisingly unclear, a growing number of roles have been attributed to extracellular ferritin, including newly described roles in iron delivery, angiogenesis, inflammation, immunity, signaling and cancer. General significance: Serum ferritin remains a clinically useful tool. Further studies on the biology of this protein may provide new biological insights.
Original language | English (US) |
---|---|
Pages (from-to) | 760-769 |
Number of pages | 10 |
Journal | Biochimica et Biophysica Acta - General Subjects |
Volume | 1800 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2010 |
Externally published | Yes |
Keywords
- Cancer
- Ferritin
- Ferritin receptor
- Inflammation
- Iron
- Iron store
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology