Abstract
Infantile hypercalcemia occurs in ∼15% of children with Williams syndrome (WS) and is typically not clinically severe. We report on 3 children with WS (confirmed with fluorescent in situ hybridization probes) who presented with severe symptomatic hypercalcemia. The first patient's severe hypercalcemia resolved with traditional therapies, whereas the subsequent 2 patients were treated with intravenously administered pamidronate after traditional measures proved only partially successful. Besides asymptomatic mild hypocalcemia, there were no complications resulting from pamidronate administration. We conclude that WS-associated hypercalcemia can be quite severe and symptomatic and that it can be successfully and safely treated with intravenously administered bisphosphonate in some cases.
Original language | English (US) |
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Pages (from-to) | 1091-1095 |
Number of pages | 5 |
Journal | Pediatrics |
Volume | 114 |
Issue number | 4 |
DOIs | |
State | Published - Oct 2004 |
Keywords
- Bisphosphonate
- Hypercalcemia
- Pamidronate
- Williams syndrome
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health