Severe therapy-related toxicities after treatment for Hodgkin lymphoma due to a pathogenic TERT variant and shortened telomeres

Jennifer E. Agrusa; Alison A. Bertuch; Courtney D. DiNardo; Sharon E. Plon; Olive S. Eckstein

doi:10.1002/pbc.27779

Severe therapy-related toxicities after treatment for Hodgkin lymphoma due to a pathogenic TERT variant and shortened telomeres

Jennifer E. Agrusa, Alison A. Bertuch, Courtney D. DiNardo, Sharon E. Plon, Olive S. Eckstein

Leukemia

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Telomere biology disorders predispose affected individuals to specific malignancies and organ fibrosis in tissues sensitive to telomere length (TL) shortening, especially after exposure to chemotherapy and radiation. We report a case of a 17-year-old female with Hodgkin lymphoma who developed severe chemotherapy-related toxicities. She was subsequently found to have peripheral blood lymphocyte TL < 1st percentile and a pathogenic variant in TERT inherited from her father. This case demonstrates that early genetic evaluation of patients who experience greater than expected therapy-related toxicities may be warranted to help guide further decisions regarding therapy, imaging modalities, and lifelong cancer prevention surveillance.

Original language	English (US)
Article number	e27779
Journal	Pediatric Blood and Cancer
Volume	66
Issue number	8
DOIs	https://doi.org/10.1002/pbc.27779
State	Published - Aug 2019

Keywords

Hodgkin disease
MDS
late effects of cancer treatment
lymphoma
molecular genetics
telomerase

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Access to Document

10.1002/pbc.27779

Cite this

@article{97276f82112a43229fa4d7146348c95a,

title = "Severe therapy-related toxicities after treatment for Hodgkin lymphoma due to a pathogenic TERT variant and shortened telomeres",

abstract = "Telomere biology disorders predispose affected individuals to specific malignancies and organ fibrosis in tissues sensitive to telomere length (TL) shortening, especially after exposure to chemotherapy and radiation. We report a case of a 17-year-old female with Hodgkin lymphoma who developed severe chemotherapy-related toxicities. She was subsequently found to have peripheral blood lymphocyte TL < 1st percentile and a pathogenic variant in TERT inherited from her father. This case demonstrates that early genetic evaluation of patients who experience greater than expected therapy-related toxicities may be warranted to help guide further decisions regarding therapy, imaging modalities, and lifelong cancer prevention surveillance.",

keywords = "Hodgkin disease, MDS, late effects of cancer treatment, lymphoma, molecular genetics, telomerase",

author = "Agrusa, {Jennifer E.} and Bertuch, {Alison A.} and DiNardo, {Courtney D.} and Plon, {Sharon E.} and Eckstein, {Olive S.}",

note = "Funding Information: University of Texas MD Anderson Cancer Center, Grant/Award Number: SPORE P50 CA10063; National Institutes of Health, Grant/Award Numbers: 2K12CA090433-16, R01 HL131744 Funding Information: This research was supported in part by the National Institutes of Health 2K12CA090433-16 (Eckstein), R01 HL131744 (Bertuch), and MD Anderson Cancer Center Leukemia SPORE P50 CA10063 (Dinardo). Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",

year = "2019",

month = aug,

doi = "10.1002/pbc.27779",

language = "English (US)",

volume = "66",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

publisher = "Wiley-Liss Inc.",

number = "8",

}

TY - JOUR

T1 - Severe therapy-related toxicities after treatment for Hodgkin lymphoma due to a pathogenic TERT variant and shortened telomeres

AU - Agrusa, Jennifer E.

AU - Bertuch, Alison A.

AU - DiNardo, Courtney D.

AU - Plon, Sharon E.

AU - Eckstein, Olive S.

N1 - Funding Information: University of Texas MD Anderson Cancer Center, Grant/Award Number: SPORE P50 CA10063; National Institutes of Health, Grant/Award Numbers: 2K12CA090433-16, R01 HL131744 Funding Information: This research was supported in part by the National Institutes of Health 2K12CA090433-16 (Eckstein), R01 HL131744 (Bertuch), and MD Anderson Cancer Center Leukemia SPORE P50 CA10063 (Dinardo). Publisher Copyright: © 2019 Wiley Periodicals, Inc.

PY - 2019/8

Y1 - 2019/8

N2 - Telomere biology disorders predispose affected individuals to specific malignancies and organ fibrosis in tissues sensitive to telomere length (TL) shortening, especially after exposure to chemotherapy and radiation. We report a case of a 17-year-old female with Hodgkin lymphoma who developed severe chemotherapy-related toxicities. She was subsequently found to have peripheral blood lymphocyte TL < 1st percentile and a pathogenic variant in TERT inherited from her father. This case demonstrates that early genetic evaluation of patients who experience greater than expected therapy-related toxicities may be warranted to help guide further decisions regarding therapy, imaging modalities, and lifelong cancer prevention surveillance.

AB - Telomere biology disorders predispose affected individuals to specific malignancies and organ fibrosis in tissues sensitive to telomere length (TL) shortening, especially after exposure to chemotherapy and radiation. We report a case of a 17-year-old female with Hodgkin lymphoma who developed severe chemotherapy-related toxicities. She was subsequently found to have peripheral blood lymphocyte TL < 1st percentile and a pathogenic variant in TERT inherited from her father. This case demonstrates that early genetic evaluation of patients who experience greater than expected therapy-related toxicities may be warranted to help guide further decisions regarding therapy, imaging modalities, and lifelong cancer prevention surveillance.

KW - Hodgkin disease

KW - MDS

KW - late effects of cancer treatment

KW - lymphoma

KW - molecular genetics

KW - telomerase

UR - http://www.scopus.com/inward/record.url?scp=85065313835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065313835&partnerID=8YFLogxK

U2 - 10.1002/pbc.27779

DO - 10.1002/pbc.27779

M3 - Article

C2 - 31050187

AN - SCOPUS:85065313835

SN - 1545-5009

VL - 66

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 8

M1 - e27779

ER -

Severe therapy-related toxicities after treatment for Hodgkin lymphoma due to a pathogenic TERT variant and shortened telomeres

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this