Sex chromosome abnormalities in lung cancer patients

Bhavana J. Dave; Vicki L. Hopwood; Margaret R. Spitz; Sen Pathak

doi:10.1016/0165-4608(95)00245-6

Sex chromosome abnormalities in lung cancer patients

Bhavana J. Dave, Vicki L. Hopwood, Margaret R. Spitz, Sen Pathak

School of Health Professions

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Chromosomal analyses of lymphocytes from lung cancer patients and normal subjects revealed that the X and the Y chromosomes have both structural and numerical abnormalities in higher frequency in patients compared to the controls. These abnormalities included chromatid/isochromatid breaks, translocations, ring formation, and selective nondisjunctions, resulting in multisomies of either the X or Y chromosomes. Possible significance of these genetic abnormalities are discussed in relation to lung cancer patients.

Original language	English (US)
Pages (from-to)	24-28
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	87
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(95)00245-6
State	Published - Mar 1996

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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title = "Sex chromosome abnormalities in lung cancer patients",

abstract = "Chromosomal analyses of lymphocytes from lung cancer patients and normal subjects revealed that the X and the Y chromosomes have both structural and numerical abnormalities in higher frequency in patients compared to the controls. These abnormalities included chromatid/isochromatid breaks, translocations, ring formation, and selective nondisjunctions, resulting in multisomies of either the X or Y chromosomes. Possible significance of these genetic abnormalities are discussed in relation to lung cancer patients.",

author = "Dave, {Bhavana J.} and Hopwood, {Vicki L.} and Spitz, {Margaret R.} and Sen Pathak",

note = "Funding Information: This work was supported in part by NIH grants CA55769 and RRO 4999-01 and a grant from the John S. Dunn Research Foundation, Houston, Texas. We thank Dahlia A. Garza for secretarial support, and Leslie Wildrick for her editorial assistance.",

year = "1996",

month = mar,

doi = "10.1016/0165-4608(95)00245-6",

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T1 - Sex chromosome abnormalities in lung cancer patients

AU - Dave, Bhavana J.

AU - Hopwood, Vicki L.

AU - Spitz, Margaret R.

AU - Pathak, Sen

N1 - Funding Information: This work was supported in part by NIH grants CA55769 and RRO 4999-01 and a grant from the John S. Dunn Research Foundation, Houston, Texas. We thank Dahlia A. Garza for secretarial support, and Leslie Wildrick for her editorial assistance.

PY - 1996/3

Y1 - 1996/3

N2 - Chromosomal analyses of lymphocytes from lung cancer patients and normal subjects revealed that the X and the Y chromosomes have both structural and numerical abnormalities in higher frequency in patients compared to the controls. These abnormalities included chromatid/isochromatid breaks, translocations, ring formation, and selective nondisjunctions, resulting in multisomies of either the X or Y chromosomes. Possible significance of these genetic abnormalities are discussed in relation to lung cancer patients.

AB - Chromosomal analyses of lymphocytes from lung cancer patients and normal subjects revealed that the X and the Y chromosomes have both structural and numerical abnormalities in higher frequency in patients compared to the controls. These abnormalities included chromatid/isochromatid breaks, translocations, ring formation, and selective nondisjunctions, resulting in multisomies of either the X or Y chromosomes. Possible significance of these genetic abnormalities are discussed in relation to lung cancer patients.

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JO - Cancer Genetics and Cytogenetics

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ER -

Sex chromosome abnormalities in lung cancer patients

Abstract

ASJC Scopus subject areas

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