TY - JOUR
T1 - Sex-determining region Y-box 2 expression predicts poor prognosis in human ovarian carcinoma
AU - Zhang, Jing
AU - Chang, Doo Young
AU - Mercado-Uribe, Imelda
AU - Liu, Jinsong
N1 - Funding Information:
J.L. was supported by an R01 grant ( R01CA131183-01A2 ) and ovarian cancer Specialized Programs of Research Excellence (SPORE) grant ( IP50CA83638 ) from the National Institutes of Health and Ovarian Cancer Research Fund . This work was also supported, in part, by the National Institutes of Health through MD Anderson's Cancer Center Support Grant ( CA016672 ). Dr D. Chang is a visiting scientist at MD Anderson Cancer Center from the Department of Obstetrics and Gynecology, Inje University Paik Hospital, Gyeonggi-do, Gyeonggi-do, Republic of Korea, and supported by the Inje Research and Scholarship Foundation in 2010.
PY - 2012/9
Y1 - 2012/9
N2 - Sex-determining region Y-box 2 is proposed to be a key transcription factor in embryonic stem cells. The known roles of sex-determining region Y-box 2 in development and cell differentiation suggest that it is relevant to the aberrant growth of tumor cells. Thus, sex-determining region Y-box 2 may play an important role in tumor progression. However, its clinical significance in human ovarian carcinoma has been uncertain until recently. The aim of the present study was to clarify the clinical role of sex-determining region Y-box 2 expression in ovarian carcinoma. Immunohistochemical staining of 540 human ovarian carcinoma samples for sex-determining region Y-box 2 was performed using tissue microarray. The associations among sex-determining region Y-box 2 expression and clinical factors (diagnosis, tumor grade, International Federation of Gynecology and Obstetrics stage, and response to chemotherapy), overall survival, and disease-free survival were analyzed. We observed sex-determining region Y-box 2 expression in 15% of the ovarian carcinoma samples. Use of the Fisher exact test suggested that sex-determining region Y-box 2 expression was associated with high-grade carcinoma (P =.009), especially high-grade serous carcinoma (P =.048); International Federation of Gynecology and Obstetrics stage (II-IV; P =.005); and malignant mixed müllerian tumors (P =.048). Sex-determining region Y-box 2 expression was also associated with decreased disease-free survival durations (P =.035; log-rank test). Our results showed that sex-determining region Y-box 2 expression may be a potential marker related to tumor recurrence, as implicated by its role in cancer stem cells.
AB - Sex-determining region Y-box 2 is proposed to be a key transcription factor in embryonic stem cells. The known roles of sex-determining region Y-box 2 in development and cell differentiation suggest that it is relevant to the aberrant growth of tumor cells. Thus, sex-determining region Y-box 2 may play an important role in tumor progression. However, its clinical significance in human ovarian carcinoma has been uncertain until recently. The aim of the present study was to clarify the clinical role of sex-determining region Y-box 2 expression in ovarian carcinoma. Immunohistochemical staining of 540 human ovarian carcinoma samples for sex-determining region Y-box 2 was performed using tissue microarray. The associations among sex-determining region Y-box 2 expression and clinical factors (diagnosis, tumor grade, International Federation of Gynecology and Obstetrics stage, and response to chemotherapy), overall survival, and disease-free survival were analyzed. We observed sex-determining region Y-box 2 expression in 15% of the ovarian carcinoma samples. Use of the Fisher exact test suggested that sex-determining region Y-box 2 expression was associated with high-grade carcinoma (P =.009), especially high-grade serous carcinoma (P =.048); International Federation of Gynecology and Obstetrics stage (II-IV; P =.005); and malignant mixed müllerian tumors (P =.048). Sex-determining region Y-box 2 expression was also associated with decreased disease-free survival durations (P =.035; log-rank test). Our results showed that sex-determining region Y-box 2 expression may be a potential marker related to tumor recurrence, as implicated by its role in cancer stem cells.
KW - Immunohistochemistry
KW - Ovarian carcinoma
KW - Prognosis
KW - Sex-determining region Y-box 2 (SOX2)
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U2 - 10.1016/j.humpath.2011.10.016
DO - 10.1016/j.humpath.2011.10.016
M3 - Article
C2 - 22401770
AN - SCOPUS:84864280124
SN - 0046-8177
VL - 43
SP - 1405
EP - 1412
JO - Human Pathology
JF - Human Pathology
IS - 9
ER -