TY - JOUR
T1 - Sex differences in the pituitary TGFβ1 system
T2 - The role of TGFβ1 in prolactinoma development
AU - Recouvreux, M. Victoria
AU - Faraoni, Erika Y.
AU - Camilletti, M. Andrea
AU - Ratner, Laura
AU - Abeledo-Machado, Alejandra
AU - Rulli, Susana B.
AU - Díaz-Torga, Graciela
N1 - Funding Information:
This work was supported by the Agencia Nacional de Promoción Científica y Técnica, Buenos Aires, Argentina (grant PICT N2136 to GDT), CONICET, Argentina (PIP 183 to SBR) and René Barón Fundation (to GDT and SBR).
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/7
Y1 - 2018/7
N2 - Prolactinomas are the most frequent functioning pituitary adenomas, and sex differences in tumor size, behavior and incidence have been described. These differences have been associated with earlier diagnosis in woman, as well as with serum estradiol levels. Experimental models of prolactinomas in rodents also show a higher incidence in females, and recent findings suggest that gender differences in the transforming growth factor beta 1 (TGFβ1) system might be involved in the sex-specific development of prolactinomas in these models. The aim of this review is to summarize the literature supporting the important role of TGFβ1 as a local modulator of pituitary lactotroph function and to provide recent evidence for TGFβ1 involvement in the sex differences found in prolactinoma development in animal models.
AB - Prolactinomas are the most frequent functioning pituitary adenomas, and sex differences in tumor size, behavior and incidence have been described. These differences have been associated with earlier diagnosis in woman, as well as with serum estradiol levels. Experimental models of prolactinomas in rodents also show a higher incidence in females, and recent findings suggest that gender differences in the transforming growth factor beta 1 (TGFβ1) system might be involved in the sex-specific development of prolactinomas in these models. The aim of this review is to summarize the literature supporting the important role of TGFβ1 as a local modulator of pituitary lactotroph function and to provide recent evidence for TGFβ1 involvement in the sex differences found in prolactinoma development in animal models.
KW - Dopamine
KW - Estradiol
KW - Prolactinoma
KW - Sex differences
KW - TGFβ1
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U2 - 10.1016/j.yfrne.2017.10.003
DO - 10.1016/j.yfrne.2017.10.003
M3 - Review article
C2 - 29074127
AN - SCOPUS:85032209355
SN - 0091-3022
VL - 50
SP - 118
EP - 122
JO - Frontiers in Neuroendocrinology
JF - Frontiers in Neuroendocrinology
ER -