TY - JOUR
T1 - Shaping of the tumor microenvironment
T2 - Stromal cells and vessels
AU - Blonska, Marzenna
AU - Agarwal, Nitin K.
AU - Vega, Francisco
PY - 2015
Y1 - 2015
N2 - Lymphomas develop and progress in a specialized tissue microenvironment such as bone marrow as well as secondary lymphoid organs such as lymph node and spleen. The lymphoma microenvironment is characterized by a heterogeneous population of stromal cells, including fibroblastic reticular cells, nurse-like cells, mesenchymal stem cells, follicular dendritic cells, and inflammatory cells such as macrophages, T- and B-cells. These cell populations interact with the lymphoma cells to promote lymphoma growth, survival and drug resistance through multiple mechanisms. Angiogenesis is also recognized as an important factor associated with lymphoma progression. In recent years, we have learned that the interaction between the malignant and non-malignant cells is bidirectional and resembles, at least in part, the pattern seen between non-neoplastic lymphoid cells and the normal microenvironment of lymphoid organs. A summary of the current knowledge of lymphoma microenvironment focusing on the cellular components will be reviewed here.
AB - Lymphomas develop and progress in a specialized tissue microenvironment such as bone marrow as well as secondary lymphoid organs such as lymph node and spleen. The lymphoma microenvironment is characterized by a heterogeneous population of stromal cells, including fibroblastic reticular cells, nurse-like cells, mesenchymal stem cells, follicular dendritic cells, and inflammatory cells such as macrophages, T- and B-cells. These cell populations interact with the lymphoma cells to promote lymphoma growth, survival and drug resistance through multiple mechanisms. Angiogenesis is also recognized as an important factor associated with lymphoma progression. In recent years, we have learned that the interaction between the malignant and non-malignant cells is bidirectional and resembles, at least in part, the pattern seen between non-neoplastic lymphoid cells and the normal microenvironment of lymphoid organs. A summary of the current knowledge of lymphoma microenvironment focusing on the cellular components will be reviewed here.
KW - Angiogenesis
KW - Hedgehog signaling
KW - Lymphoma microenvironment
KW - NF-κB signaling
KW - Stromal cells
UR - http://www.scopus.com/inward/record.url?scp=84925437168&partnerID=8YFLogxK
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U2 - 10.1016/j.semcancer.2015.03.002
DO - 10.1016/j.semcancer.2015.03.002
M3 - Article
C2 - 25794825
SN - 1044-579X
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
ER -