Shift of immunoglobulin phenotypes in B-cell precursor cell lines

Stefan Faderl; Zeev Estrov

doi:10.1016/S0145-2126(01)00089-3

Shift of immunoglobulin phenotypes in B-cell precursor cell lines

Stefan Faderl, Zeev Estrov

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Rearrangement of immunoglobulin chain genes is a hallmark of mammalian B cell development and differential expression of immunoglobulin chains has aided in the diagnosis and prognostication of patients with ALL. Matsu et al. describe two novel precursor B-cell lines with shift of expression of immunoglobulin phenotypes at diagnosis and relapse. The impact of this observation on diagnosis and the elucidation of the biology of the neoplastic cells will be discussed.

Original language	English (US)
Pages (from-to)	11-12
Number of pages	2
Journal	Leukemia Research
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/S0145-2126(01)00089-3
State	Published - 2002

Keywords

Acute lymphoblastic leukemia
Heavy chain
Immunoglobulin

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/S0145-2126(01)00089-3

Cite this

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title = "Shift of immunoglobulin phenotypes in B-cell precursor cell lines",

abstract = "Rearrangement of immunoglobulin chain genes is a hallmark of mammalian B cell development and differential expression of immunoglobulin chains has aided in the diagnosis and prognostication of patients with ALL. Matsu et al. describe two novel precursor B-cell lines with shift of expression of immunoglobulin phenotypes at diagnosis and relapse. The impact of this observation on diagnosis and the elucidation of the biology of the neoplastic cells will be discussed.",

keywords = "Acute lymphoblastic leukemia, Heavy chain, Immunoglobulin",

author = "Stefan Faderl and Zeev Estrov",

year = "2002",

doi = "10.1016/S0145-2126(01)00089-3",

language = "English (US)",

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journal = "Leukemia Research",

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T1 - Shift of immunoglobulin phenotypes in B-cell precursor cell lines

AU - Faderl, Stefan

AU - Estrov, Zeev

PY - 2002

Y1 - 2002

N2 - Rearrangement of immunoglobulin chain genes is a hallmark of mammalian B cell development and differential expression of immunoglobulin chains has aided in the diagnosis and prognostication of patients with ALL. Matsu et al. describe two novel precursor B-cell lines with shift of expression of immunoglobulin phenotypes at diagnosis and relapse. The impact of this observation on diagnosis and the elucidation of the biology of the neoplastic cells will be discussed.

AB - Rearrangement of immunoglobulin chain genes is a hallmark of mammalian B cell development and differential expression of immunoglobulin chains has aided in the diagnosis and prognostication of patients with ALL. Matsu et al. describe two novel precursor B-cell lines with shift of expression of immunoglobulin phenotypes at diagnosis and relapse. The impact of this observation on diagnosis and the elucidation of the biology of the neoplastic cells will be discussed.

KW - Acute lymphoblastic leukemia

KW - Heavy chain

KW - Immunoglobulin

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UR - http://www.scopus.com/inward/citedby.url?scp=0036131793&partnerID=8YFLogxK

U2 - 10.1016/S0145-2126(01)00089-3

DO - 10.1016/S0145-2126(01)00089-3

M3 - Comment/debate

C2 - 11734298

AN - SCOPUS:0036131793

SN - 0145-2126

VL - 26

SP - 11

EP - 12

JO - Leukemia Research

JF - Leukemia Research

IS - 1

ER -

Shift of immunoglobulin phenotypes in B-cell precursor cell lines

Abstract

Keywords

ASJC Scopus subject areas

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