TY - JOUR
T1 - Short report
T2 - Emergence of new alleles of the MSP-3́ gene in Plasmodium vivax isolates from Korea
AU - Nam, Deok Hwa
AU - Oh, Jun Seo
AU - Nam, Myoung Hyun
AU - Park, Hae Chul
AU - Lim, Chae Seung
AU - Lee, Won Ja
AU - Sattabongkot, Jetsumon
AU - Klein, Terry A.
AU - Ayala, Francisco J.
PY - 2010/4
Y1 - 2010/4
N2 - Nucleotide sequence analysis of the Plasmodium vivax PvMSP-3α gene was conducted on blood from 143 malaria patients admitted to Korea University Medical Center from 1996 to 2007 in the Republic of Korea (ROK). From 1996 to 2002, the PvMSP-3α alleles were of two types, SKOR-67 (2.53 kb) and SKOR-69 (1.78 kb), which differed in length and amino acid sequence. Two new variants with similar size to SKOR-67 were first observed in 2002 and in 2006-2007 accounted for nearly 50% (25/51) of the sampled isolates. The new variants had the same amino acid sequence as SKOR-69 in the N-terminal region, but in Blocks I and II and in the C-terminal region, they were similar to previously reported isolates from Thailand, Papua New Guinea, India, Brazil, and Ecuador strains.
AB - Nucleotide sequence analysis of the Plasmodium vivax PvMSP-3α gene was conducted on blood from 143 malaria patients admitted to Korea University Medical Center from 1996 to 2007 in the Republic of Korea (ROK). From 1996 to 2002, the PvMSP-3α alleles were of two types, SKOR-67 (2.53 kb) and SKOR-69 (1.78 kb), which differed in length and amino acid sequence. Two new variants with similar size to SKOR-67 were first observed in 2002 and in 2006-2007 accounted for nearly 50% (25/51) of the sampled isolates. The new variants had the same amino acid sequence as SKOR-69 in the N-terminal region, but in Blocks I and II and in the C-terminal region, they were similar to previously reported isolates from Thailand, Papua New Guinea, India, Brazil, and Ecuador strains.
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U2 - 10.4269/ajtmh.2010.08-0332
DO - 10.4269/ajtmh.2010.08-0332
M3 - Article
C2 - 20348492
AN - SCOPUS:77950931890
SN - 0002-9637
VL - 82
SP - 522
EP - 524
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 4
ER -