Short-Term Changes in Skeletal Muscle Mass After Anthracycline Administration in Adolescent and Young Adult Sarcoma Patients

Savannah V. Wooten; Michael Roth; John Andrew Livingston; Michelle A.T. Hildebrandt; Joya Chandra; Behrang Amini; Eugenie S. Kleinerman; Susan C. Gilchrist

doi:10.1089/jayao.2021.0107

Short-Term Changes in Skeletal Muscle Mass After Anthracycline Administration in Adolescent and Young Adult Sarcoma Patients

Savannah V. Wooten, Michael Roth, John Andrew Livingston, Michelle A.T. Hildebrandt, Joya Chandra, Behrang Amini, Eugenie S. Kleinerman, Susan C. Gilchrist

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Identification of anthracycline-induced muscle loss is critical for maintaining health in adolescent and young adult (AYA) cancer patients. We used routine chest computed tomography (CT) scans to investigate changes in skeletal muscle of 16 AYA sarcoma patients at thoracic vertebrae 4 (T4) after anthracycline treatment. CT images were examined at three time points (prechemotherapy, postchemotherapy, and 1 year). Significant changes in total skeletal muscle index and density were seen after chemotherapy (p = 0.021 and p = 0.016, respectively) and at 1 year versus baseline (both p < 0.05). This study supports the use of T4 as an early indicator of skeletal muscle loss in AYAs.

Original language	English (US)
Pages (from-to)	320-322
Number of pages	3
Journal	Journal of adolescent and young adult oncology
Volume	11
Issue number	3
DOIs	https://doi.org/10.1089/jayao.2021.0107
State	Published - Jun 1 2022

Keywords

T4
anthracyclines
computed tomography
muscle loss
sarcoma
sarcopenia

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Oncology

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10.1089/jayao.2021.0107

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title = "Short-Term Changes in Skeletal Muscle Mass After Anthracycline Administration in Adolescent and Young Adult Sarcoma Patients",

abstract = "Identification of anthracycline-induced muscle loss is critical for maintaining health in adolescent and young adult (AYA) cancer patients. We used routine chest computed tomography (CT) scans to investigate changes in skeletal muscle of 16 AYA sarcoma patients at thoracic vertebrae 4 (T4) after anthracycline treatment. CT images were examined at three time points (prechemotherapy, postchemotherapy, and 1 year). Significant changes in total skeletal muscle index and density were seen after chemotherapy (p = 0.021 and p = 0.016, respectively) and at 1 year versus baseline (both p < 0.05). This study supports the use of T4 as an early indicator of skeletal muscle loss in AYAs.",

keywords = "T4, anthracyclines, computed tomography, muscle loss, sarcoma, sarcopenia",

author = "Wooten, {Savannah V.} and Michael Roth and Livingston, {John Andrew} and Hildebrandt, {Michelle A.T.} and Joya Chandra and Behrang Amini and Kleinerman, {Eugenie S.} and Gilchrist, {Susan C.}",

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doi = "10.1089/jayao.2021.0107",

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T1 - Short-Term Changes in Skeletal Muscle Mass After Anthracycline Administration in Adolescent and Young Adult Sarcoma Patients

AU - Wooten, Savannah V.

AU - Roth, Michael

AU - Livingston, John Andrew

AU - Hildebrandt, Michelle A.T.

AU - Chandra, Joya

AU - Amini, Behrang

AU - Kleinerman, Eugenie S.

AU - Gilchrist, Susan C.

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Identification of anthracycline-induced muscle loss is critical for maintaining health in adolescent and young adult (AYA) cancer patients. We used routine chest computed tomography (CT) scans to investigate changes in skeletal muscle of 16 AYA sarcoma patients at thoracic vertebrae 4 (T4) after anthracycline treatment. CT images were examined at three time points (prechemotherapy, postchemotherapy, and 1 year). Significant changes in total skeletal muscle index and density were seen after chemotherapy (p = 0.021 and p = 0.016, respectively) and at 1 year versus baseline (both p < 0.05). This study supports the use of T4 as an early indicator of skeletal muscle loss in AYAs.

AB - Identification of anthracycline-induced muscle loss is critical for maintaining health in adolescent and young adult (AYA) cancer patients. We used routine chest computed tomography (CT) scans to investigate changes in skeletal muscle of 16 AYA sarcoma patients at thoracic vertebrae 4 (T4) after anthracycline treatment. CT images were examined at three time points (prechemotherapy, postchemotherapy, and 1 year). Significant changes in total skeletal muscle index and density were seen after chemotherapy (p = 0.021 and p = 0.016, respectively) and at 1 year versus baseline (both p < 0.05). This study supports the use of T4 as an early indicator of skeletal muscle loss in AYAs.

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KW - computed tomography

KW - muscle loss

KW - sarcoma

KW - sarcopenia

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Short-Term Changes in Skeletal Muscle Mass After Anthracycline Administration in Adolescent and Young Adult Sarcoma Patients

Abstract

Keywords

ASJC Scopus subject areas

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