Abstract
HER-2/neu (also called erbB2) encodes a 185-kd tyrosine kinase receptor, named p185, belonging to the class I receptor subfamily. Aberrant expression of HER-2/neu is implicated in many human cancers. An understanding of the signaling pathway of p185 may shed light on the mechanism involved in p185- mediated neoplastic transformation or carcinogenesis. This article reviews recent work on the signal transduction of p185.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 109-118 |
| Number of pages | 10 |
| Journal | Cancer Bulletin |
| Volume | 47 |
| Issue number | 2 |
| State | Published - 1995 |
ASJC Scopus subject areas
- Cancer Research