Abstract
c-Jun N-terminal kinase (JNK) is one of the several main MAP kinase groups identified in mammals. Original studies by use of Jurkat T cells implicated JNK in T cell activation and interleukin (IL-2) expression. Recent advances using mouse genetic approaches have revealed novel functions of this pathway in primary mouse T cells. JNK is not essential for T-cell activation; instead, it is required for helper T differentiation into effector cells and their cytokine production. In this review, we summarize these advances in understanding the expression, function, and regulation of the JNK pathway in T-lymphocyte activation and differentiation.
Original language | English (US) |
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Pages (from-to) | 253-257 |
Number of pages | 5 |
Journal | Journal of Clinical Immunology |
Volume | 21 |
Issue number | 4 |
DOIs | |
State | Published - 2001 |
Keywords
- C-Jun N-terminal kinase
- T helper 1 (Th1)
- T lymphocytes
- Th2
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology