Significance of fibrinogen, D-dimer, and LDH levels in predicting the risk of bleeding in patients with acute promyelocytic leukemia

Dae Young Kim; Je Hwan Lee; Jung Hee Lee; Sung Doo Kim; Sung Nam Lim; Yunsuk Choi; Young Shin Lee; Young Ah Kang; Miee Seol; Mijin Jeon; Joo Youn Kim; Kyung Hwa Lee; Yeon Joo Lee; Kyoo Hyung Lee

doi:10.1016/j.leukres.2010.05.022

Significance of fibrinogen, D-dimer, and LDH levels in predicting the risk of bleeding in patients with acute promyelocytic leukemia

Dae Young Kim, Je Hwan Lee, Jung Hee Lee, Sung Doo Kim, Sung Nam Lim, Yunsuk Choi, Young Shin Lee, Young Ah Kang, Miee Seol, Mijin Jeon, Joo Youn Kim, Kyung Hwa Lee, Yeon Joo Lee, Kyoo Hyung Lee

Lymphoma-Myeloma

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39 Scopus citations

Abstract

This study was performed to determine whether any clinical parameters measured at diagnosis or during treatment are associated with bleeding in patients with acute promyelocytic leukemia (APL). Ninety patients with APL who were treated with all-transretinoic acid (ATRA) and anthracycline-based chemotherapy were analyzed. There were 24 significant bleeding events, classified by onset as 'hyperacute' (n= 5), 'acute' (n= 11) and 'late' (n= 8). Fifteen patients (17%) died because of bleeding. A poor fibrinogen (FBG) response during ATRA and chemotherapy was associated with an increased risk of bleeding (p= 0.003). Increased LDH and decreased FBG levels were associated with an increased incidence of bleeding, and low PLT count was correlated with death from bleeding. Our findings suggest that LDH/FBG levels and FBG response may be associated with morbidity and mortality from bleeding in patients with APL.

Original language	English (US)
Pages (from-to)	152-158
Number of pages	7
Journal	Leukemia Research
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/j.leukres.2010.05.022
State	Published - Feb 2011

Keywords

ATRA
Acute promyelocytic leukemia
Bleeding
D-dimer
Fibrinogen
LDH

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2010.05.022

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Kim, D. Y., Lee, J. H., Lee, J. H., Kim, S. D., Lim, S. N., Choi, Y., Lee, Y. S., Kang, Y. A., Seol, M., Jeon, M., Kim, J. Y., Lee, K. H., Lee, Y. J., & Lee, K. H. (2011). Significance of fibrinogen, D-dimer, and LDH levels in predicting the risk of bleeding in patients with acute promyelocytic leukemia. Leukemia Research, 35(2), 152-158. https://doi.org/10.1016/j.leukres.2010.05.022

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title = "Significance of fibrinogen, D-dimer, and LDH levels in predicting the risk of bleeding in patients with acute promyelocytic leukemia",

abstract = "This study was performed to determine whether any clinical parameters measured at diagnosis or during treatment are associated with bleeding in patients with acute promyelocytic leukemia (APL). Ninety patients with APL who were treated with all-transretinoic acid (ATRA) and anthracycline-based chemotherapy were analyzed. There were 24 significant bleeding events, classified by onset as 'hyperacute' (n= 5), 'acute' (n= 11) and 'late' (n= 8). Fifteen patients (17%) died because of bleeding. A poor fibrinogen (FBG) response during ATRA and chemotherapy was associated with an increased risk of bleeding (p= 0.003). Increased LDH and decreased FBG levels were associated with an increased incidence of bleeding, and low PLT count was correlated with death from bleeding. Our findings suggest that LDH/FBG levels and FBG response may be associated with morbidity and mortality from bleeding in patients with APL.",

keywords = "ATRA, Acute promyelocytic leukemia, Bleeding, D-dimer, Fibrinogen, LDH",

author = "Kim, {Dae Young} and Lee, {Je Hwan} and Lee, {Jung Hee} and Kim, {Sung Doo} and Lim, {Sung Nam} and Yunsuk Choi and Lee, {Young Shin} and Kang, {Young Ah} and Miee Seol and Mijin Jeon and Kim, {Joo Youn} and Lee, {Kyung Hwa} and Lee, {Yeon Joo} and Lee, {Kyoo Hyung}",

note = "Funding Information: This study was supported by a grant ( 2009-477 ) from the Asan Institute for Life Sciences, Seoul, Korea . ",

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doi = "10.1016/j.leukres.2010.05.022",

language = "English (US)",

volume = "35",

pages = "152--158",

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T1 - Significance of fibrinogen, D-dimer, and LDH levels in predicting the risk of bleeding in patients with acute promyelocytic leukemia

AU - Kim, Dae Young

AU - Lee, Je Hwan

AU - Lee, Jung Hee

AU - Kim, Sung Doo

AU - Lim, Sung Nam

AU - Choi, Yunsuk

AU - Lee, Young Shin

AU - Kang, Young Ah

AU - Seol, Miee

AU - Jeon, Mijin

AU - Kim, Joo Youn

AU - Lee, Kyung Hwa

AU - Lee, Yeon Joo

AU - Lee, Kyoo Hyung

N1 - Funding Information: This study was supported by a grant ( 2009-477 ) from the Asan Institute for Life Sciences, Seoul, Korea .

PY - 2011/2

Y1 - 2011/2

N2 - This study was performed to determine whether any clinical parameters measured at diagnosis or during treatment are associated with bleeding in patients with acute promyelocytic leukemia (APL). Ninety patients with APL who were treated with all-transretinoic acid (ATRA) and anthracycline-based chemotherapy were analyzed. There were 24 significant bleeding events, classified by onset as 'hyperacute' (n= 5), 'acute' (n= 11) and 'late' (n= 8). Fifteen patients (17%) died because of bleeding. A poor fibrinogen (FBG) response during ATRA and chemotherapy was associated with an increased risk of bleeding (p= 0.003). Increased LDH and decreased FBG levels were associated with an increased incidence of bleeding, and low PLT count was correlated with death from bleeding. Our findings suggest that LDH/FBG levels and FBG response may be associated with morbidity and mortality from bleeding in patients with APL.

AB - This study was performed to determine whether any clinical parameters measured at diagnosis or during treatment are associated with bleeding in patients with acute promyelocytic leukemia (APL). Ninety patients with APL who were treated with all-transretinoic acid (ATRA) and anthracycline-based chemotherapy were analyzed. There were 24 significant bleeding events, classified by onset as 'hyperacute' (n= 5), 'acute' (n= 11) and 'late' (n= 8). Fifteen patients (17%) died because of bleeding. A poor fibrinogen (FBG) response during ATRA and chemotherapy was associated with an increased risk of bleeding (p= 0.003). Increased LDH and decreased FBG levels were associated with an increased incidence of bleeding, and low PLT count was correlated with death from bleeding. Our findings suggest that LDH/FBG levels and FBG response may be associated with morbidity and mortality from bleeding in patients with APL.

KW - ATRA

KW - Acute promyelocytic leukemia

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KW - D-dimer

KW - Fibrinogen

KW - LDH

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Significance of fibrinogen, D-dimer, and LDH levels in predicting the risk of bleeding in patients with acute promyelocytic leukemia

Abstract

Keywords

ASJC Scopus subject areas

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