TY - JOUR
T1 - Significance of tumor size and radiation dose to local control in Stage I-III diffuse large cell lymphoma treated with CHOP-Bleo and radiation
AU - Fuller, Lillian M.
AU - Krasin, Matthew J.
AU - Velasquez, William S.
AU - Allen, Pamela K.
AU - McLaughlin, Peter
AU - Rodriguez, M. Alma
AU - Hagemeister, Fredrick B.
AU - Swan, Forrest
AU - Cabanillas, Fernando
AU - Palmer, Judy L.
AU - Cox, James D.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Purpose: The purpose of this study was ti evaluate the possible effect of adjunctive involve field (IF) radiotherapy on long-term local control for patients with Ann Arbor Stage I-III diffuse large cell lymphoma (DLCL) who achieved a complete remission on a combined modality program which included cyclophosphamide, doxorubicin, vincristine, prednisone, and Bleomycin (CHOP-Belo). Methods and Materials: One hundred and ninety patients with Ann Arbor Stage I-III DLCL were treated with CHOP-Bleo and radiotherapy. Analyses were undertaken to determine (a) response to treatment according to stage, extent of maximum local disease, and irradiation dose either < 40 Gy or ≥ 40 Gy and (b) relapse patterns. Results: A complete remission (CR) was achieved in 162 patients. Among patients who achieved a CR, local control was better for those who received tumor doses of ≥ 40 Gy (97%) than for those who received < 40 Gy (83%) (p = 0.002.) Among those with extensive local disease, the corresponding control rates were 88% and 71%, respectively. A study of distant relapse patterns following a CR showed that the first relapse usually involved an extranodal site. Conclusion: Radiotherapy was an effective adjunctive treatment to CHOP-Bleo for patients with stage I-III DLCL who achieved a CR. Patterns of relapse suggested that total nodal irradiation (TNI) possibly could have benefited a small subset of patients.
AB - Purpose: The purpose of this study was ti evaluate the possible effect of adjunctive involve field (IF) radiotherapy on long-term local control for patients with Ann Arbor Stage I-III diffuse large cell lymphoma (DLCL) who achieved a complete remission on a combined modality program which included cyclophosphamide, doxorubicin, vincristine, prednisone, and Bleomycin (CHOP-Belo). Methods and Materials: One hundred and ninety patients with Ann Arbor Stage I-III DLCL were treated with CHOP-Bleo and radiotherapy. Analyses were undertaken to determine (a) response to treatment according to stage, extent of maximum local disease, and irradiation dose either < 40 Gy or ≥ 40 Gy and (b) relapse patterns. Results: A complete remission (CR) was achieved in 162 patients. Among patients who achieved a CR, local control was better for those who received tumor doses of ≥ 40 Gy (97%) than for those who received < 40 Gy (83%) (p = 0.002.) Among those with extensive local disease, the corresponding control rates were 88% and 71%, respectively. A study of distant relapse patterns following a CR showed that the first relapse usually involved an extranodal site. Conclusion: Radiotherapy was an effective adjunctive treatment to CHOP-Bleo for patients with stage I-III DLCL who achieved a CR. Patterns of relapse suggested that total nodal irradiation (TNI) possibly could have benefited a small subset of patients.
KW - CHOP-Bleo
KW - Diffuse large cell lymphoma
KW - Radiotherapy
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U2 - 10.1016/0360-3016(94)00343-J
DO - 10.1016/0360-3016(94)00343-J
M3 - Article
C2 - 7527799
AN - SCOPUS:0028894673
SN - 0360-3016
VL - 31
SP - 3
EP - 11
JO - International journal of radiation oncology, biology, physics
JF - International journal of radiation oncology, biology, physics
IS - 1
ER -