Similar brain tau pathology in DM2/PROMM and DM1/Steinert disease

C. A. Maurage; B. Udd; M. M. Ruchoux; P. Vermersch; H. Kalimo; R. Krahe; A. Delacourte; N. Sergeant

doi:10.1212/01.wnl.0000184585.93864.4e

Similar brain tau pathology in DM2/PROMM and DM1/Steinert disease

C. A. Maurage, B. Udd, M. M. Ruchoux, P. Vermersch, H. Kalimo, R. Krahe, A. Delacourte, N. Sergeant

Genetics

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Neurofibrillary degeneration (NFD) occurs in the brains of patients with myotonic dystrophy (DM) type 1. The authors report a similar tau pathology in the CNS of a patient with DM2 and compare it to that of patients with DM1. A reduced expression of tau exon 2 and exon 3 epitopes is observed in both DM1 and DM2. This suggests a similar physiopathologic process that may contribute to common neurologic features in patients with DM.

Original language	English (US)
Pages (from-to)	1636-1638
Number of pages	3
Journal	Neurology
Volume	65
Issue number	10
DOIs	https://doi.org/10.1212/01.wnl.0000184585.93864.4e
State	Published - Nov 2005

ASJC Scopus subject areas

Clinical Neurology

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10.1212/01.wnl.0000184585.93864.4e

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title = "Similar brain tau pathology in DM2/PROMM and DM1/Steinert disease",

abstract = "Neurofibrillary degeneration (NFD) occurs in the brains of patients with myotonic dystrophy (DM) type 1. The authors report a similar tau pathology in the CNS of a patient with DM2 and compare it to that of patients with DM1. A reduced expression of tau exon 2 and exon 3 epitopes is observed in both DM1 and DM2. This suggests a similar physiopathologic process that may contribute to common neurologic features in patients with DM.",

author = "Maurage, {C. A.} and B. Udd and Ruchoux, {M. M.} and P. Vermersch and H. Kalimo and R. Krahe and A. Delacourte and N. Sergeant",

note = "Funding Information: Supported by INSERM and AFM, by grants from EA 2691 MENRT, the Liv and Halsa Foundation in Finland, and the Research Funds of the Vasa Central Hospital. ",

year = "2005",

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doi = "10.1212/01.wnl.0000184585.93864.4e",

language = "English (US)",

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T1 - Similar brain tau pathology in DM2/PROMM and DM1/Steinert disease

AU - Maurage, C. A.

AU - Udd, B.

AU - Ruchoux, M. M.

AU - Vermersch, P.

AU - Kalimo, H.

AU - Krahe, R.

AU - Delacourte, A.

AU - Sergeant, N.

N1 - Funding Information: Supported by INSERM and AFM, by grants from EA 2691 MENRT, the Liv and Halsa Foundation in Finland, and the Research Funds of the Vasa Central Hospital.

PY - 2005/11

Y1 - 2005/11

N2 - Neurofibrillary degeneration (NFD) occurs in the brains of patients with myotonic dystrophy (DM) type 1. The authors report a similar tau pathology in the CNS of a patient with DM2 and compare it to that of patients with DM1. A reduced expression of tau exon 2 and exon 3 epitopes is observed in both DM1 and DM2. This suggests a similar physiopathologic process that may contribute to common neurologic features in patients with DM.

AB - Neurofibrillary degeneration (NFD) occurs in the brains of patients with myotonic dystrophy (DM) type 1. The authors report a similar tau pathology in the CNS of a patient with DM2 and compare it to that of patients with DM1. A reduced expression of tau exon 2 and exon 3 epitopes is observed in both DM1 and DM2. This suggests a similar physiopathologic process that may contribute to common neurologic features in patients with DM.

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Similar brain tau pathology in DM2/PROMM and DM1/Steinert disease

Abstract

ASJC Scopus subject areas

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