Single dose response curves of murine gastrointestinal crypt stem cells

K. Masuda, H. R. Withers, K. A. Mason, K. Y. Chen

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Dose response curves for the reproductive capacity of crypt stem cells of murine colonic, jejunal, and gastric mucosae exposed in situ to multifractionated gamma ray exposures were analyzed and single dose survival curves of these cells were constructed. The following conclusions were drawn: (1) The single dose response curves bend downward over a dose range of approximately 200 to 1500 rad; (2) cell death seems to be due to nonrepairable damage at doses less than 250 rad for colon, and 220 rad for jejunum; (3) there are 21, 110, and 140 stem cells per crypt of gastric, colonic, and jejunal mucosa, respectively; and (4) jejunal stem cells are the most radiosensitive and gastric mucosal stem cells are the most resistant.

Original languageEnglish (US)
Pages (from-to)65-75
Number of pages11
JournalRadiation Research
Volume69
Issue number1
DOIs
StatePublished - Jan 1 1977

Fingerprint

stem cells
Stem Cells
dosage
curves
Stomach
Gamma Rays
Jejunum
Gastric Mucosa
Cell Survival
Colon
Mucous Membrane
Cell Death
death
gamma rays
damage
cells

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

Cite this

Masuda, K., Withers, H. R., Mason, K. A., & Chen, K. Y. (1977). Single dose response curves of murine gastrointestinal crypt stem cells. Radiation Research, 69(1), 65-75. https://doi.org/10.2307/3574517

Single dose response curves of murine gastrointestinal crypt stem cells. / Masuda, K.; Withers, H. R.; Mason, K. A.; Chen, K. Y.

In: Radiation Research, Vol. 69, No. 1, 01.01.1977, p. 65-75.

Research output: Contribution to journalArticle

Masuda, K, Withers, HR, Mason, KA & Chen, KY 1977, 'Single dose response curves of murine gastrointestinal crypt stem cells', Radiation Research, vol. 69, no. 1, pp. 65-75. https://doi.org/10.2307/3574517
Masuda, K. ; Withers, H. R. ; Mason, K. A. ; Chen, K. Y. / Single dose response curves of murine gastrointestinal crypt stem cells. In: Radiation Research. 1977 ; Vol. 69, No. 1. pp. 65-75.
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