Abstract
Dose response curves for the reproductive capacity of crypt stem cells of murine colonic, jejunal, and gastric mucosae exposed in situ to multifractionated gamma ray exposures were analyzed and single dose survival curves of these cells were constructed. The following conclusions were drawn: (1) The single dose response curves bend downward over a dose range of approximately 200 to 1500 rad; (2) cell death seems to be due to nonrepairable damage at doses less than 250 rad for colon, and 220 rad for jejunum; (3) there are 21, 110, and 140 stem cells per crypt of gastric, colonic, and jejunal mucosa, respectively; and (4) jejunal stem cells are the most radiosensitive and gastric mucosal stem cells are the most resistant.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 65-75 |
| Number of pages | 11 |
| Journal | Radiation research |
| Volume | 69 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1977 |
ASJC Scopus subject areas
- Radiation
- Biophysics
- Radiology Nuclear Medicine and imaging