Single Photon Emission Computed Tomography and Positron Emission Tomography Imaging of Multi-drug Resistant P-glycoprotein-Monitoring a Transport Activity Important in Cancer, Blood-Brain Barrier Function and Alzheimer's Disease

David Piwnica-Worms; Aparna H. Kesarwala; Andrea Pichler; Julie L. Prior; Vijay Sharma

doi:10.1016/j.nic.2006.06.007

Single Photon Emission Computed Tomography and Positron Emission Tomography Imaging of Multi-drug Resistant P-glycoprotein-Monitoring a Transport Activity Important in Cancer, Blood-Brain Barrier Function and Alzheimer's Disease

David Piwnica-Worms, Aparna H. Kesarwala, Andrea Pichler, Julie L. Prior, Vijay Sharma

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Several radiopharmaceuticals enable SPECT and PET monitoring of Pgp-mediated transport activity in tissues in vivo. There is significant promise for noninvasive assessment of Pgp to guide choices of chemotherapy regimens, monitor MDR gene therapy, and assess a potential risk factor for development of AD at the level of the BBB.

Original language	English (US)
Pages (from-to)	575-589
Number of pages	15
Journal	Neuroimaging Clinics of North America
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/j.nic.2006.06.007
State	Published - Nov 2006
Externally published	Yes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Clinical Neurology

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10.1016/j.nic.2006.06.007

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Piwnica-Worms, D., Kesarwala, A. H., Pichler, A., Prior, J. L., & Sharma, V. (2006). Single Photon Emission Computed Tomography and Positron Emission Tomography Imaging of Multi-drug Resistant P-glycoprotein-Monitoring a Transport Activity Important in Cancer, Blood-Brain Barrier Function and Alzheimer's Disease. Neuroimaging Clinics of North America, 16(4), 575-589. https://doi.org/10.1016/j.nic.2006.06.007

Single Photon Emission Computed Tomography and Positron Emission Tomography Imaging of Multi-drug Resistant P-glycoprotein-Monitoring a Transport Activity Important in Cancer, Blood-Brain Barrier Function and Alzheimer's Disease. / Piwnica-Worms, David; Kesarwala, Aparna H.; Pichler, Andrea et al.
In: Neuroimaging Clinics of North America, Vol. 16, No. 4, 11.2006, p. 575-589.

Research output: Contribution to journal › Review article › peer-review

Piwnica-Worms, D, Kesarwala, AH, Pichler, A, Prior, JL & Sharma, V 2006, 'Single Photon Emission Computed Tomography and Positron Emission Tomography Imaging of Multi-drug Resistant P-glycoprotein-Monitoring a Transport Activity Important in Cancer, Blood-Brain Barrier Function and Alzheimer's Disease', Neuroimaging Clinics of North America, vol. 16, no. 4, pp. 575-589. https://doi.org/10.1016/j.nic.2006.06.007

Piwnica-Worms D, Kesarwala AH, Pichler A, Prior JL, Sharma V. Single Photon Emission Computed Tomography and Positron Emission Tomography Imaging of Multi-drug Resistant P-glycoprotein-Monitoring a Transport Activity Important in Cancer, Blood-Brain Barrier Function and Alzheimer's Disease. Neuroimaging Clinics of North America. 2006 Nov;16(4):575-589. doi: 10.1016/j.nic.2006.06.007

Piwnica-Worms, David ; Kesarwala, Aparna H. ; Pichler, Andrea et al. / Single Photon Emission Computed Tomography and Positron Emission Tomography Imaging of Multi-drug Resistant P-glycoprotein-Monitoring a Transport Activity Important in Cancer, Blood-Brain Barrier Function and Alzheimer's Disease. In: Neuroimaging Clinics of North America. 2006 ; Vol. 16, No. 4. pp. 575-589.

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