Abstract
The most commonly encountered carcinoma of the sinonasal tract is the keratinizing/ non-keratinizing squamous cell carcinoma. However, this complex anatomic location may represent the site of other epithelial malignant neoplasms of varying histogenesis. These tumors are clinically aggressive and often fatal; historically, treatment outcomes have been poor. Differentiating these tumor types may have clinical impact as advances in therapeutic intervention could increase survival, quality of life and occasionally result in a cure. This review focuses on recent advances in the molecular and phenotypic characterization of sinonasal carcinomas and their impact on diagnosis and treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 218-224 |
| Number of pages | 7 |
| Journal | Current Cancer Therapy Reviews |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2012 |
Keywords
- Genome analysis
- Phenotype
- Sinonasal carcinoma
- Targeted therapy
ASJC Scopus subject areas
- Molecular Medicine
- Oncology
- Cancer Research