TY - JOUR
T1 - Sinonasal Hamartomas
T2 - From Nasal Chondromesenchymal Hamartoma to Respiratory Epithelial Adenomatoid Hamartoma. Report of six Cases and Review of the Literature
AU - Li, Rongying
AU - Saluja, Karan
AU - Lin, Mei
AU - Hu, Zhihong
AU - Cai, Zhenjian
AU - Zhu, Hui
N1 - Publisher Copyright:
© The Author(s) 2022.
PY - 2022/6
Y1 - 2022/6
N2 - Sinonasal hamartomas are uncommon lesions of nasal and sinus cavities. Based on indigenous cellular components and characteristic histologic features, they are further classified into four entities: respiratory epithelial adenomatoid hamartoma (REAH), seromucinous hamartoma (SH), chondro-osseous and respiratory epithelial hamartoma (CORE), and nasal chondromesenchymal hamartoma (NCH). REAH, SH, and CORE are seen in adult patients, while NCH predominantly occurs in newborns and infants. Morphologically REAH and SH are composed of respiratory epithelium and seromucinous glands, CORE is related to REAH but with additional feature of chondroid and/or osseous tissue, and NCH is composed of chondroid and stromal elements but devoid of epithelial component. All four lesions can present as sinonasal mass lesions and with associated obstructive symptoms. Given the rarity of these lesions, diagnosis can be challenging, especially in unusual clinical scenario. In this study, we report six cases of sinonasal hamartoma, including one case of NCH, one case of CORE, two cases of SH, and two cases of REAH. All cases were from adult patients including four men and two women. We also review the literature of the clinical and pathologic features of these rare lesions.
AB - Sinonasal hamartomas are uncommon lesions of nasal and sinus cavities. Based on indigenous cellular components and characteristic histologic features, they are further classified into four entities: respiratory epithelial adenomatoid hamartoma (REAH), seromucinous hamartoma (SH), chondro-osseous and respiratory epithelial hamartoma (CORE), and nasal chondromesenchymal hamartoma (NCH). REAH, SH, and CORE are seen in adult patients, while NCH predominantly occurs in newborns and infants. Morphologically REAH and SH are composed of respiratory epithelium and seromucinous glands, CORE is related to REAH but with additional feature of chondroid and/or osseous tissue, and NCH is composed of chondroid and stromal elements but devoid of epithelial component. All four lesions can present as sinonasal mass lesions and with associated obstructive symptoms. Given the rarity of these lesions, diagnosis can be challenging, especially in unusual clinical scenario. In this study, we report six cases of sinonasal hamartoma, including one case of NCH, one case of CORE, two cases of SH, and two cases of REAH. All cases were from adult patients including four men and two women. We also review the literature of the clinical and pathologic features of these rare lesions.
KW - chondro-osseous and respiratory epithelial hamartoma
KW - nasal chondromesenchymal hamartoma
KW - respiratory epithelial adenomatoid hamartoma
KW - seromucinous hamartoma
KW - sinonasal hamartoma
UR - http://www.scopus.com/inward/record.url?scp=85122656112&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85122656112&partnerID=8YFLogxK
U2 - 10.1177/10668969211064211
DO - 10.1177/10668969211064211
M3 - Article
C2 - 35001691
AN - SCOPUS:85122656112
SN - 1066-8969
VL - 30
SP - 448
EP - 456
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
IS - 4
ER -