Sinonasal neuroendocrine carcinoma: Impact of differentiation status on response and outcome

Anna Likhacheva; David Rosenthal; Ehab Hanna; Michael Kupferman; Franco Demonte; Adel El-Naggar

doi:10.1186/1758-3284-3-32

Sinonasal neuroendocrine carcinoma: Impact of differentiation status on response and outcome

Anna Likhacheva, David Rosenthal, Ehab Hanna, Michael Kupferman, Franco Demonte, Adel El-Naggar

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49 Scopus citations

Abstract

Background: The impact of tumor differentiation on the behavior and response of sinonasal neuroendocrine carcinoma is unknown. Methods. We performed a retrospective review of the patients treated for neuroendocrine carcinoma (NEC) of the nasal cavity or paranasal sinuses from 1992 to 2008 at MDACC. Results: The results of our study suggest that pathologic differentiation may not be a critical factor in the clinical management of patients with NEC of the sinonasal tract. This is in contrast to laryngeal and lung NEC for which pathological differentiation has traditionally guided clinical management. Conclusion: Mutlimodality approach should be the cornerstone of treating sinonasal NEC regardless of their differentiation. Specifically, RT may provide durable local control for patients with moderately differentiated NEC if resection is not feasible or desirable, while surgical resection can benefit patients with chemo-resistant or radio-resistant disease.

Original language	English (US)
Article number	32
Journal	Head and Neck Oncology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1186/1758-3284-3-32
State	Published - 2011

Keywords

Neuroendocrine carcinoma
carcinoid tumor
poorly differentiated carcinoma
sinonasal tumor

ASJC Scopus subject areas

Otorhinolaryngology
Oncology

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10.1186/1758-3284-3-32

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title = "Sinonasal neuroendocrine carcinoma: Impact of differentiation status on response and outcome",

abstract = "Background: The impact of tumor differentiation on the behavior and response of sinonasal neuroendocrine carcinoma is unknown. Methods. We performed a retrospective review of the patients treated for neuroendocrine carcinoma (NEC) of the nasal cavity or paranasal sinuses from 1992 to 2008 at MDACC. Results: The results of our study suggest that pathologic differentiation may not be a critical factor in the clinical management of patients with NEC of the sinonasal tract. This is in contrast to laryngeal and lung NEC for which pathological differentiation has traditionally guided clinical management. Conclusion: Mutlimodality approach should be the cornerstone of treating sinonasal NEC regardless of their differentiation. Specifically, RT may provide durable local control for patients with moderately differentiated NEC if resection is not feasible or desirable, while surgical resection can benefit patients with chemo-resistant or radio-resistant disease.",

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T2 - Impact of differentiation status on response and outcome

AU - Likhacheva, Anna

AU - Rosenthal, David

AU - Hanna, Ehab

AU - Kupferman, Michael

AU - Demonte, Franco

AU - El-Naggar, Adel

PY - 2011

Y1 - 2011

N2 - Background: The impact of tumor differentiation on the behavior and response of sinonasal neuroendocrine carcinoma is unknown. Methods. We performed a retrospective review of the patients treated for neuroendocrine carcinoma (NEC) of the nasal cavity or paranasal sinuses from 1992 to 2008 at MDACC. Results: The results of our study suggest that pathologic differentiation may not be a critical factor in the clinical management of patients with NEC of the sinonasal tract. This is in contrast to laryngeal and lung NEC for which pathological differentiation has traditionally guided clinical management. Conclusion: Mutlimodality approach should be the cornerstone of treating sinonasal NEC regardless of their differentiation. Specifically, RT may provide durable local control for patients with moderately differentiated NEC if resection is not feasible or desirable, while surgical resection can benefit patients with chemo-resistant or radio-resistant disease.

AB - Background: The impact of tumor differentiation on the behavior and response of sinonasal neuroendocrine carcinoma is unknown. Methods. We performed a retrospective review of the patients treated for neuroendocrine carcinoma (NEC) of the nasal cavity or paranasal sinuses from 1992 to 2008 at MDACC. Results: The results of our study suggest that pathologic differentiation may not be a critical factor in the clinical management of patients with NEC of the sinonasal tract. This is in contrast to laryngeal and lung NEC for which pathological differentiation has traditionally guided clinical management. Conclusion: Mutlimodality approach should be the cornerstone of treating sinonasal NEC regardless of their differentiation. Specifically, RT may provide durable local control for patients with moderately differentiated NEC if resection is not feasible or desirable, while surgical resection can benefit patients with chemo-resistant or radio-resistant disease.

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KW - carcinoid tumor

KW - poorly differentiated carcinoma

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Sinonasal neuroendocrine carcinoma: Impact of differentiation status on response and outcome

Abstract

Keywords

ASJC Scopus subject areas

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