Sinonasal NUT carcinoma: A consecutive case series and systematic review

Uma Ramesh; Kevin J. Contrera; Nasim Shakibai; Shirley Y. Su; Bledi Brahimaj; Dianna Roberts; Michelle D. Williams; Renata Ferrarotto; Jack Phan; Gary Brandon Gunn; Shaan Raza; Franco DeMonte; Ehab Y. Hanna

doi:10.1002/hed.27553

Sinonasal NUT carcinoma: A consecutive case series and systematic review

Uma Ramesh, Kevin J. Contrera, Nasim Shakibai, Shirley Y. Su, Bledi Brahimaj, Dianna Roberts, Michelle D. Williams, Renata Ferrarotto, Jack Phan, Gary Brandon Gunn, Shaan Raza, Franco DeMonte, Ehab Y. Hanna

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: Sinonasal NUT carcinoma is an extremely rare, lethal malignancy with limited literature. Methods: A case series was conduction of all patients with sinonasal NUT carcinoma at a single institution between 2010 and 2022. Survival and associated were evaluated. A systematic review of the literature was performed. Results: In 12 patients, followed for a median of 1.5 years, the median overall survival (OS) and disease-specific survival (DSS) were both 14.6 months. Patients with maxillary sinus tumors were 91% more likely to survive (hazard ratio [HR]: 0.094, 95% confidence interval [CI]: 0.011–0.78, p = 0.011). Patients with higher-stage disease stage had worse OS (stage IVb-c vs. III-IVa, p = 0.05). All three patients who were alive with no evidence of disease received induction chemotherapy. Conclusion: For patients with sinonasal NUT carcinoma, the median survival was 15 months but better with lower-stage and maxillary tumors. Induction chemotherapy may be beneficial.

Original language	English (US)
Pages (from-to)	29-36
Number of pages	8
Journal	Head and Neck
Volume	46
Issue number	1
DOIs	https://doi.org/10.1002/hed.27553
State	Published - Jan 2024

Keywords

carcinoma
induction chemotherapy
neoadjuvant
NUT
sinonasal

ASJC Scopus subject areas

Otorhinolaryngology

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title = "Sinonasal NUT carcinoma: A consecutive case series and systematic review",

abstract = "Background: Sinonasal NUT carcinoma is an extremely rare, lethal malignancy with limited literature. Methods: A case series was conduction of all patients with sinonasal NUT carcinoma at a single institution between 2010 and 2022. Survival and associated were evaluated. A systematic review of the literature was performed. Results: In 12 patients, followed for a median of 1.5 years, the median overall survival (OS) and disease-specific survival (DSS) were both 14.6 months. Patients with maxillary sinus tumors were 91% more likely to survive (hazard ratio [HR]: 0.094, 95% confidence interval [CI]: 0.011–0.78, p = 0.011). Patients with higher-stage disease stage had worse OS (stage IVb-c vs. III-IVa, p = 0.05). All three patients who were alive with no evidence of disease received induction chemotherapy. Conclusion: For patients with sinonasal NUT carcinoma, the median survival was 15 months but better with lower-stage and maxillary tumors. Induction chemotherapy may be beneficial.",

keywords = "carcinoma, induction chemotherapy, neoadjuvant, NUT, sinonasal",

author = "Uma Ramesh and Contrera, {Kevin J.} and Nasim Shakibai and Su, {Shirley Y.} and Bledi Brahimaj and Dianna Roberts and Williams, {Michelle D.} and Renata Ferrarotto and Jack Phan and Gunn, {Gary Brandon} and Shaan Raza and Franco DeMonte and Hanna, {Ehab Y.}",

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year = "2024",

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doi = "10.1002/hed.27553",

language = "English (US)",

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T2 - A consecutive case series and systematic review

AU - Ramesh, Uma

AU - Contrera, Kevin J.

AU - Shakibai, Nasim

AU - Su, Shirley Y.

AU - Brahimaj, Bledi

AU - Roberts, Dianna

AU - Williams, Michelle D.

AU - Ferrarotto, Renata

AU - Phan, Jack

AU - Gunn, Gary Brandon

AU - Raza, Shaan

AU - DeMonte, Franco

AU - Hanna, Ehab Y.

PY - 2024/1

Y1 - 2024/1

N2 - Background: Sinonasal NUT carcinoma is an extremely rare, lethal malignancy with limited literature. Methods: A case series was conduction of all patients with sinonasal NUT carcinoma at a single institution between 2010 and 2022. Survival and associated were evaluated. A systematic review of the literature was performed. Results: In 12 patients, followed for a median of 1.5 years, the median overall survival (OS) and disease-specific survival (DSS) were both 14.6 months. Patients with maxillary sinus tumors were 91% more likely to survive (hazard ratio [HR]: 0.094, 95% confidence interval [CI]: 0.011–0.78, p = 0.011). Patients with higher-stage disease stage had worse OS (stage IVb-c vs. III-IVa, p = 0.05). All three patients who were alive with no evidence of disease received induction chemotherapy. Conclusion: For patients with sinonasal NUT carcinoma, the median survival was 15 months but better with lower-stage and maxillary tumors. Induction chemotherapy may be beneficial.

AB - Background: Sinonasal NUT carcinoma is an extremely rare, lethal malignancy with limited literature. Methods: A case series was conduction of all patients with sinonasal NUT carcinoma at a single institution between 2010 and 2022. Survival and associated were evaluated. A systematic review of the literature was performed. Results: In 12 patients, followed for a median of 1.5 years, the median overall survival (OS) and disease-specific survival (DSS) were both 14.6 months. Patients with maxillary sinus tumors were 91% more likely to survive (hazard ratio [HR]: 0.094, 95% confidence interval [CI]: 0.011–0.78, p = 0.011). Patients with higher-stage disease stage had worse OS (stage IVb-c vs. III-IVa, p = 0.05). All three patients who were alive with no evidence of disease received induction chemotherapy. Conclusion: For patients with sinonasal NUT carcinoma, the median survival was 15 months but better with lower-stage and maxillary tumors. Induction chemotherapy may be beneficial.

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KW - neoadjuvant

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KW - sinonasal

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Sinonasal NUT carcinoma: A consecutive case series and systematic review

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