Abstract
Sinonasal undifferentiated carcinoma is a highly aggressive lesion arising in the superior nasal cavity and paranasal sinuses. Differential diagnosis is wide because a range of similar lesions can present at this site. There is increasing evidence that sinonasal undifferentiated carcinoma is a surface (Schneiderian) epithelial-derived malignancy, with or without concurrent neuroendocrine differentiation. Prognosis is poor; recurrence with metastasis to lymph nodes and distant sites is frequent. A combination of radical surgery, chemotherapy and radiotherapy appears to provide the best chance of survival.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 285-296 |
| Number of pages | 12 |
| Journal | Expert review of anticancer therapy |
| Volume | 13 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2013 |
Keywords
- histogenesis
- multi-institutional
- multimodality therapy
- sinonasal undifferentiated carcinoma
- targeted molecular therapy
ASJC Scopus subject areas
- Oncology
- Pharmacology (medical)