Abstract
RNA interference (RNAi), discovered in the latter part of the 20 th century is a promising technology for use in curing intractable genetic diseases by the sequence-specific cleavage of mRNA. Since incorporation of siRNA into the multi-protein RNA-Induced Silencing Complex (RISC) is a key process for siRNA activity, efficient cytoplasmic delivery system is essential for the application of siRNA in clinical use. In the present manuscript, we introduce our recent approach to control an intracellular trafficking of siRNA by means of multifunctional envelope-type nano device (MEND).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 590-597 |
| Number of pages | 8 |
| Journal | Drug Delivery System |
| Volume | 25 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2010 |
Keywords
- Decoating
- Endosome escape
- Intracellular trafficking
- MEND
- siRNA
ASJC Scopus subject areas
- Pharmaceutical Science