SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Shoshana Naiman; Frank K. Huynh; Reuven Gil; Yair Glick; Yael Shahar; Noga Touitou; Liat Nahum; Matan Y. Avivi; Asael Roichman; Yariv Kanfi; Asaf A. Gertler; Tirza Doniger; Olga R. Ilkayeva; Ifat Abramovich; Orly Yaron; Batia Lerrer; Eyal Gottlieb; Robert A. Harris; Doron Gerber; Matthew D. Hirschey; Haim Y. Cohen

doi:10.1016/j.celrep.2019.11.067

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Shoshana Naiman, Frank K. Huynh, Reuven Gil, Yair Glick, Yael Shahar, Noga Touitou, Liat Nahum, Matan Y. Avivi, Asael Roichman, Yariv Kanfi, Asaf A. Gertler, Tirza Doniger, Olga R. Ilkayeva, Ifat Abramovich, Orly Yaron, Batia Lerrer, Eyal Gottlieb, Robert A. Harris, Doron Gerber, Matthew D. HirscheyHaim Y. Cohen

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.

Original language	English (US)
Pages (from-to)	4127-4143.e8
Journal	Cell Reports
Volume	29
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2019.11.067
State	Published - Dec 17 2019
Externally published	Yes

Keywords

beta-oxidation
deacetylase
fasting
liver
PPARα
SIRT6

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2019.11.067

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Naiman, S., Huynh, F. K., Gil, R., Glick, Y., Shahar, Y., Touitou, N., Nahum, L., Avivi, M. Y., Roichman, A., Kanfi, Y., Gertler, A. A., Doniger, T., Ilkayeva, O. R., Abramovich, I., Yaron, O., Lerrer, B., Gottlieb, E., Harris, R. A., Gerber, D., ... Cohen, H. Y. (2019). SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα. Cell Reports, 29(12), 4127-4143.e8. https://doi.org/10.1016/j.celrep.2019.11.067

Naiman, S, Huynh, FK, Gil, R, Glick, Y, Shahar, Y, Touitou, N, Nahum, L, Avivi, MY, Roichman, A, Kanfi, Y, Gertler, AA, Doniger, T, Ilkayeva, OR, Abramovich, I, Yaron, O, Lerrer, B, Gottlieb, E, Harris, RA, Gerber, D, Hirschey, MD & Cohen, HY 2019, 'SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα', Cell Reports, vol. 29, no. 12, pp. 4127-4143.e8. https://doi.org/10.1016/j.celrep.2019.11.067

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abstract = "How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.",

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AU - Huynh, Frank K.

AU - Gil, Reuven

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AU - Shahar, Yael

AU - Touitou, Noga

AU - Nahum, Liat

AU - Avivi, Matan Y.

AU - Roichman, Asael

AU - Kanfi, Yariv

AU - Gertler, Asaf A.

AU - Doniger, Tirza

AU - Ilkayeva, Olga R.

AU - Abramovich, Ifat

AU - Yaron, Orly

AU - Lerrer, Batia

AU - Gottlieb, Eyal

AU - Harris, Robert A.

AU - Gerber, Doron

AU - Hirschey, Matthew D.

AU - Cohen, Haim Y.

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KW - beta-oxidation

KW - deacetylase

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KW - liver

KW - PPARα

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SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

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Keywords

ASJC Scopus subject areas

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