TY - JOUR
T1 - Size and shape effects in the biodistribution of intravascularly injected particles
AU - Decuzzi, P.
AU - Godin, B.
AU - Tanaka, T.
AU - Lee, S. Y.
AU - Chiappini, C.
AU - Liu, X.
AU - Ferrari, M.
N1 - Funding Information:
The authors would like to acknowledge support from the State of Texas's Emerging Technology Fund , NASA ( NNJ06HE06A ), Department of Defense ( W81XWH-07-2-0101 , W31P4Q-07-1-0008 , and W81XWH-09-1-0212 ), National Institute of Health ( R01CA128797 ) and the Alliance for NanoHealth (ANH) . Paolo Decuzzi acknowledges support also from the European Science Foundation EUROCORES Programme FANAS , through funds by the Consiglio Nazionale delle Ricerche and the EC Sixth Framework Programme under contract N. ERAS-CT-2003-980409FANAS .
PY - 2010/2
Y1 - 2010/2
N2 - Understanding how size and shape can affect the biodistribution of intravascularly injected particles is of fundamental importance both for the rational design of delivery systems and from a standardization and regulatory view point. In this work, uncoated silica spherical beads, with a diameter ranging from 700 nm to 3 μm, and uncoated non-spherical silicon-based particles, with quasi-hemispherical, cylindrical and discoidal shapes, have been injected into tumor bearing mice. The number of particles accumulating in the major organs and within the tumor mass has been measured through elemental silicon (Si) analysis. For the spherical beads, it has been found that the number of particles accumulating in the non-RES organs reduces monotonically as the diameter . d increases, suggesting the use of smaller particles to provide a more uniform tissue distribution. However, discoidal particles have been observed to accumulate more than others in most of the organs but the liver, where cylindrical particles are deposited at a larger extent. These preliminary results support the notion of using sub-micrometer discoidal particles as intravascular carriers to maximize accumulation in the target organ whilst reducing sequestration by the liver.
AB - Understanding how size and shape can affect the biodistribution of intravascularly injected particles is of fundamental importance both for the rational design of delivery systems and from a standardization and regulatory view point. In this work, uncoated silica spherical beads, with a diameter ranging from 700 nm to 3 μm, and uncoated non-spherical silicon-based particles, with quasi-hemispherical, cylindrical and discoidal shapes, have been injected into tumor bearing mice. The number of particles accumulating in the major organs and within the tumor mass has been measured through elemental silicon (Si) analysis. For the spherical beads, it has been found that the number of particles accumulating in the non-RES organs reduces monotonically as the diameter . d increases, suggesting the use of smaller particles to provide a more uniform tissue distribution. However, discoidal particles have been observed to accumulate more than others in most of the organs but the liver, where cylindrical particles are deposited at a larger extent. These preliminary results support the notion of using sub-micrometer discoidal particles as intravascular carriers to maximize accumulation in the target organ whilst reducing sequestration by the liver.
KW - Delivery systems
KW - Particle shape
KW - Particle size
KW - RES
KW - Vascular adhesion
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U2 - 10.1016/j.jconrel.2009.10.014
DO - 10.1016/j.jconrel.2009.10.014
M3 - Article
C2 - 19874859
AN - SCOPUS:75549087322
SN - 0168-3659
VL - 141
SP - 320
EP - 327
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 3
ER -