TY - JOUR
T1 - Skin and superficial soft tissue neoplasms with multinucleated giant cells
T2 - Clinical, histologic, phenotypic, and molecular differentiating features
AU - Aramin, Hermineh
AU - Zaleski, Michael
AU - Prieto, Victor G.
AU - Aung, Phyu P.
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/10
Y1 - 2019/10
N2 - Multinucleated giant cells (MGC) are commonly seen in an array of neoplastic and non-neoplastic conditions, to include: granulomatous dermatitis, fibrohistiocytic lesions such as xanthogranulomas, and soft tissue tumors such as giant cell tumors of soft tissue. In addition, multinucleated giant cells are infrequently seen in melanoma, squamous cell carcinoma, and atypical fibroxanthoma. There are many different types of MGCs and their presence, cytologic, and immunohistochemical features within these pathologic entities vary. Thus, correct identification of the different types of MGCs can aid the practicing pathologist in making the correct diagnosis of the overall pathologic disease. The biologic diversity and variation of MGCs is currently best exemplified in cytologic appearance and immunohistochemical profiles. However, much remains unknown about the origination and evolution. In this review, we i) reflect on the various types of MGCs and the current understanding of their divergent development, ii) describe the histologic, immunohistochemical, and molecular (if previously reported) differentiating features of common skin and superficial soft tissue neoplasms that may present with multinucleated giant cells.
AB - Multinucleated giant cells (MGC) are commonly seen in an array of neoplastic and non-neoplastic conditions, to include: granulomatous dermatitis, fibrohistiocytic lesions such as xanthogranulomas, and soft tissue tumors such as giant cell tumors of soft tissue. In addition, multinucleated giant cells are infrequently seen in melanoma, squamous cell carcinoma, and atypical fibroxanthoma. There are many different types of MGCs and their presence, cytologic, and immunohistochemical features within these pathologic entities vary. Thus, correct identification of the different types of MGCs can aid the practicing pathologist in making the correct diagnosis of the overall pathologic disease. The biologic diversity and variation of MGCs is currently best exemplified in cytologic appearance and immunohistochemical profiles. However, much remains unknown about the origination and evolution. In this review, we i) reflect on the various types of MGCs and the current understanding of their divergent development, ii) describe the histologic, immunohistochemical, and molecular (if previously reported) differentiating features of common skin and superficial soft tissue neoplasms that may present with multinucleated giant cells.
KW - Atypical fibroxanthoma
KW - Giant cell tumor of soft tissue
KW - Juvenile xanthogranuloma
KW - Melanoma
KW - Multinucleated giant cell
KW - Reticulohistiocytomas
KW - Squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85068745299&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068745299&partnerID=8YFLogxK
U2 - 10.1016/j.anndiagpath.2019.06.013
DO - 10.1016/j.anndiagpath.2019.06.013
M3 - Review article
C2 - 31306855
AN - SCOPUS:85068745299
SN - 1092-9134
VL - 42
SP - 18
EP - 32
JO - Annals of Diagnostic Pathology
JF - Annals of Diagnostic Pathology
ER -