TY - JOUR
T1 - Sleep disruption in hematopoietic cell transplantation recipients
T2 - Prevalence, severity, and clinical management
AU - Jim, Heather S.L.
AU - Evans, Bryan
AU - Jeong, Jiyeon M.
AU - Gonzalez, Brian D.
AU - Johnston, Laura
AU - Nelson, Ashley M.
AU - Kesler, Shelli
AU - Phillips, Kristin M.
AU - Barata, Anna
AU - Pidala, Joseph
AU - Palesh, Oxana
N1 - Funding Information:
Financial disclosure: Supported by National Cancer Institute grant K07 CA138499 (to H.S.L.J.), National Cancer Institute grant K07 CA132916 (to O.P.), and the Stanford Cancer Institute Seed Award (to O.P.).
Publisher Copyright:
© 2014 American Society for Blood and Marrow Transplantation.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Sleep disruption is common among hematopoietic cell transplant (HCT) recipients, with over 50% of recipients experiencing sleep disruption pre-transplant, with up to 82% of patients experiencing moderate to severe sleep disruption during hospitalization for transplant and up to 43% after transplant. These rates of sleep disruption are substantially higher than what we see in the general population. Although sleep disruption can be distressing to patients and contribute to diminished quality of life, it is rarely discussed during clinical visits. The goal of the current review is to draw attention to sleep disruption and disorders (ie, insomnia, obstructive sleep apnea, restless legs syndrome) as a clinical problem in HCT in order to facilitate patient education, intervention, and research. We identified 35 observational studies published in the past decade that examined sleep disruption or disorders in HCT. Most studies utilized a single item measure of sleep, had small sample size, and included heterogeneous samples of patients. Six studies of the effects of psychosocial and exercise interventions on sleep in HCT have reported no significant improvements. These results highlight the need for rigorous observational and interventional studies of sleep disruption and disorders in HCT recipients.
AB - Sleep disruption is common among hematopoietic cell transplant (HCT) recipients, with over 50% of recipients experiencing sleep disruption pre-transplant, with up to 82% of patients experiencing moderate to severe sleep disruption during hospitalization for transplant and up to 43% after transplant. These rates of sleep disruption are substantially higher than what we see in the general population. Although sleep disruption can be distressing to patients and contribute to diminished quality of life, it is rarely discussed during clinical visits. The goal of the current review is to draw attention to sleep disruption and disorders (ie, insomnia, obstructive sleep apnea, restless legs syndrome) as a clinical problem in HCT in order to facilitate patient education, intervention, and research. We identified 35 observational studies published in the past decade that examined sleep disruption or disorders in HCT. Most studies utilized a single item measure of sleep, had small sample size, and included heterogeneous samples of patients. Six studies of the effects of psychosocial and exercise interventions on sleep in HCT have reported no significant improvements. These results highlight the need for rigorous observational and interventional studies of sleep disruption and disorders in HCT recipients.
KW - Hematopoietic cell transplant
KW - Management of sleep disruption
KW - Sleep disruption
UR - http://www.scopus.com/inward/record.url?scp=84912520877&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84912520877&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2014.04.010
DO - 10.1016/j.bbmt.2014.04.010
M3 - Review article
C2 - 24747335
AN - SCOPUS:84912520877
SN - 1083-8791
VL - 20
SP - 1465
EP - 1484
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 10
ER -