TY - JOUR
T1 - Sleep duration and incidence of colorectal cancer in postmenopausal women
AU - Jiao, L.
AU - Duan, Z.
AU - Sangi-Haghpeykar, H.
AU - Hale, L.
AU - White, D. L.
AU - El-Serag, H. B.
N1 - Funding Information:
This work was supported by the Women’s Health Initiative Programme, which is funded by the National Heart, Lung, and Blood Institute at the National Institutes of Health, US Department of Health and Human Services (contract number N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32, and 44221). Dr Jiao is supported by Dan Duncan Scholar Award, Gillson Longenbaugh Foundation, and Golfers Against Cancer Organisation. Dr El-Serag is supported by grant DK078154-03 from the National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). Dr White was supported by grant DK081736-01 from the NIDDK. This material is based upon work supported in part by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, and the Houston VA Health Services Research and Development Centre of Excellence (HFP90-020), as well as DK58338 from the NIDDK. We thank the WHI investigators and staff for their dedication, and the study participants for making the programme possible. A listing of WHI investigators can be found at http://www.whiscience.org/ publications/WHI_investigators_shortlist.pdf.
PY - 2013/1/15
Y1 - 2013/1/15
N2 - Background:Sleep duration is dependent on circadian rhythm that controls a variety of key cellular functions. Circadian disruption has been implicated in colorectal tumorigenesis in experimental studies. We prospectively examined the association between sleep duration and risk of colorectal cancer (CRC).Methods:In the Women's Health Initiative Observational Study, 75 828 postmenopausal women reported habitual sleep duration at baseline 1993-1998. We used Cox proportional hazards regression model to estimate the hazard ratio (HR) of CRC and its associated 95% confidence interval (CI).Results:We ascertained 851 incident cases of CRC through 2010, with an average 11.3 years of follow-up. Compared with 7 h of sleep, the HRs were 1.36 (95% CI 1.06-1.74) and 1.47 (95% CI 1.10-1.96) for short (≤5 h) and long (≥9 h) sleep duration, respectively, after adjusting for age, ethnicity, fatigue, hormone replacement therapy (HRT), physical activity, and waist to hip ratio. The association was modified by the use of HRT (P-interaction=0.03).Conclusion:Both extreme short and long sleep durations were associated with a moderate increase in the risk of CRC in postmenopausal women. Sleep duration may be a novel, independent, and potentially modifiable risk factor for CRC.
AB - Background:Sleep duration is dependent on circadian rhythm that controls a variety of key cellular functions. Circadian disruption has been implicated in colorectal tumorigenesis in experimental studies. We prospectively examined the association between sleep duration and risk of colorectal cancer (CRC).Methods:In the Women's Health Initiative Observational Study, 75 828 postmenopausal women reported habitual sleep duration at baseline 1993-1998. We used Cox proportional hazards regression model to estimate the hazard ratio (HR) of CRC and its associated 95% confidence interval (CI).Results:We ascertained 851 incident cases of CRC through 2010, with an average 11.3 years of follow-up. Compared with 7 h of sleep, the HRs were 1.36 (95% CI 1.06-1.74) and 1.47 (95% CI 1.10-1.96) for short (≤5 h) and long (≥9 h) sleep duration, respectively, after adjusting for age, ethnicity, fatigue, hormone replacement therapy (HRT), physical activity, and waist to hip ratio. The association was modified by the use of HRT (P-interaction=0.03).Conclusion:Both extreme short and long sleep durations were associated with a moderate increase in the risk of CRC in postmenopausal women. Sleep duration may be a novel, independent, and potentially modifiable risk factor for CRC.
KW - Sleep
KW - colorectal neoplasms
KW - prospective studies
KW - risk factors
KW - women
UR - http://www.scopus.com/inward/record.url?scp=84872609628&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872609628&partnerID=8YFLogxK
U2 - 10.1038/bjc.2012.561
DO - 10.1038/bjc.2012.561
M3 - Article
C2 - 23287986
AN - SCOPUS:84872609628
SN - 0007-0920
VL - 108
SP - 213
EP - 221
JO - British journal of cancer
JF - British journal of cancer
IS - 1
ER -