TY - JOUR
T1 - Small bowel adenocarcinoma
T2 - Etiology, presentation, and molecular alterations
AU - Pedersen, Katrina S.
AU - Raghav, Kanwal
AU - Overman, Michael J.
N1 - Publisher Copyright:
© 2019 Harborside Press. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Small bowel adenocarcinoma (SBA) is a rare cancer that has been treated similarly to colorectal cancer (CRC) in the advanced setting. Incidence has been increasing as detection efforts have been improving for these challenging-to-diagnose tumors, but patients frequently experience prolonged nonspecific symptoms due to delayed diagnosis. As a result of such delays and likely due to variant biology, patient outcomes for SBA are inferior to those for CRC at all stages of diagnosis. Recent molecular studies highlight the genomic differences underpinning these tumors and suggest new future pathways for treatment, distinct from CRC.
AB - Small bowel adenocarcinoma (SBA) is a rare cancer that has been treated similarly to colorectal cancer (CRC) in the advanced setting. Incidence has been increasing as detection efforts have been improving for these challenging-to-diagnose tumors, but patients frequently experience prolonged nonspecific symptoms due to delayed diagnosis. As a result of such delays and likely due to variant biology, patient outcomes for SBA are inferior to those for CRC at all stages of diagnosis. Recent molecular studies highlight the genomic differences underpinning these tumors and suggest new future pathways for treatment, distinct from CRC.
UR - http://www.scopus.com/inward/record.url?scp=85071752513&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071752513&partnerID=8YFLogxK
U2 - 10.6004/jnccn.2019.7344
DO - 10.6004/jnccn.2019.7344
M3 - Review article
C2 - 31487680
AN - SCOPUS:85071752513
SN - 1540-1405
VL - 17
SP - 1135
EP - 1141
JO - JNCCN Journal of the National Comprehensive Cancer Network
JF - JNCCN Journal of the National Comprehensive Cancer Network
IS - 9
ER -