Social disruption alters pain and cognition in an animal model of multiple sclerosis

H. R. Linsenbardt; J. L. Cook; E. E. Young; E. G. Vichaya; C. R. Young; N. M. Reusser; R. Storts; C. J. Welsh; M. W. Meagher

doi:10.1016/j.jneuroim.2015.09.005

Social disruption alters pain and cognition in an animal model of multiple sclerosis

H. R. Linsenbardt, J. L. Cook, E. E. Young, E. G. Vichaya, C. R. Young, N. M. Reusser, R. Storts, C. J. Welsh, M. W. Meagher

Symptom Research CAO

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Although pain and cognitive deficits are widespread and debilitating symptoms of multiple sclerosis (MS), they remain poorly understood. Theiler's murine encephalomyelitis virus (TMEV) infection is an animal model of MS where disease course is exacerbated by prior stressors. Here chronic infection coupled with prior social stress increased pain behavior and impaired hippocampal-dependent memory consolidation during the demyelinating phase of disease in SJL mice. These results suggest that the TMEV model may be useful in investigating pain and cognitive impairments in MS. However, in contrast to prior Balb/cJ studies, stress failed to consistently alter behavioral and physiological indicators of disease course.

Original language	English (US)
Pages (from-to)	56-68
Number of pages	13
Journal	Journal of Neuroimmunology
Volume	288
DOIs	https://doi.org/10.1016/j.jneuroim.2015.09.005
State	Published - Nov 15 2015

Keywords

Cognition
Multiple sclerosis
Pain
Pavlovian conditioning
Social stress
Theiler's murine encephalomyelitis virus

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2015.09.005

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title = "Social disruption alters pain and cognition in an animal model of multiple sclerosis",

abstract = "Although pain and cognitive deficits are widespread and debilitating symptoms of multiple sclerosis (MS), they remain poorly understood. Theiler's murine encephalomyelitis virus (TMEV) infection is an animal model of MS where disease course is exacerbated by prior stressors. Here chronic infection coupled with prior social stress increased pain behavior and impaired hippocampal-dependent memory consolidation during the demyelinating phase of disease in SJL mice. These results suggest that the TMEV model may be useful in investigating pain and cognitive impairments in MS. However, in contrast to prior Balb/cJ studies, stress failed to consistently alter behavioral and physiological indicators of disease course.",

keywords = "Cognition, Multiple sclerosis, Pain, Pavlovian conditioning, Social stress, Theiler's murine encephalomyelitis virus",

author = "Linsenbardt, {H. R.} and Cook, {J. L.} and Young, {E. E.} and Vichaya, {E. G.} and Young, {C. R.} and Reusser, {N. M.} and R. Storts and Welsh, {C. J.} and Meagher, {M. W.}",

note = "Funding Information: This research was supported by NIH/NINDS R01-NS060822 awarded to MWM and CJW and a Heep Fellowship from the Heep Foundation - Texas A&M University Foundation to HRL. The authors would also like to thank Erich Spoor for help with brain histology. Publisher Copyright: {\textcopyright} 2015 Elsevier B.V..",

year = "2015",

month = nov,

day = "15",

doi = "10.1016/j.jneuroim.2015.09.005",

language = "English (US)",

volume = "288",

pages = "56--68",

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TY - JOUR

T1 - Social disruption alters pain and cognition in an animal model of multiple sclerosis

AU - Linsenbardt, H. R.

AU - Cook, J. L.

AU - Young, E. E.

AU - Vichaya, E. G.

AU - Young, C. R.

AU - Reusser, N. M.

AU - Storts, R.

AU - Welsh, C. J.

AU - Meagher, M. W.

N1 - Funding Information: This research was supported by NIH/NINDS R01-NS060822 awarded to MWM and CJW and a Heep Fellowship from the Heep Foundation - Texas A&M University Foundation to HRL. The authors would also like to thank Erich Spoor for help with brain histology. Publisher Copyright: © 2015 Elsevier B.V..

PY - 2015/11/15

Y1 - 2015/11/15

N2 - Although pain and cognitive deficits are widespread and debilitating symptoms of multiple sclerosis (MS), they remain poorly understood. Theiler's murine encephalomyelitis virus (TMEV) infection is an animal model of MS where disease course is exacerbated by prior stressors. Here chronic infection coupled with prior social stress increased pain behavior and impaired hippocampal-dependent memory consolidation during the demyelinating phase of disease in SJL mice. These results suggest that the TMEV model may be useful in investigating pain and cognitive impairments in MS. However, in contrast to prior Balb/cJ studies, stress failed to consistently alter behavioral and physiological indicators of disease course.

AB - Although pain and cognitive deficits are widespread and debilitating symptoms of multiple sclerosis (MS), they remain poorly understood. Theiler's murine encephalomyelitis virus (TMEV) infection is an animal model of MS where disease course is exacerbated by prior stressors. Here chronic infection coupled with prior social stress increased pain behavior and impaired hippocampal-dependent memory consolidation during the demyelinating phase of disease in SJL mice. These results suggest that the TMEV model may be useful in investigating pain and cognitive impairments in MS. However, in contrast to prior Balb/cJ studies, stress failed to consistently alter behavioral and physiological indicators of disease course.

KW - Cognition

KW - Multiple sclerosis

KW - Pain

KW - Pavlovian conditioning

KW - Social stress

KW - Theiler's murine encephalomyelitis virus

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SN - 0165-5728

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SP - 56

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JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Social disruption alters pain and cognition in an animal model of multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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