TY - JOUR
T1 - Sodium thiosulfate in the treatment of non-uremic calciphylaxis
AU - Ning, Matthew S.
AU - Dahir, Kathryn M.
AU - Castellanos, Emily H.
AU - McGirt, Laura Y.
PY - 2013/8
Y1 - 2013/8
N2 - Calciphylaxis is a metastatic calcification-induced vasculopathy that results in the occlusion of small blood vessels. Although calciphylaxis is normally associated with end-stage renal disease, calciphylaxis from non-uremic origin occurs as well. While the number of reports continues to increase, a standard treatment for non-uremic calciphylaxis has yet to be established. Sodium thiosulfate (STS), which has been proven to be effective in the treatment of uremic calciphylaxis, shows promise; however, reports of its use in non-uremic cases are limited. We describe a case of non-uremic calciphylaxis in a patient with normal renal and parathyroid function who had complete resolution of disease after treatment with STS, and we review similar cases in the published work. Based on the successful outcomes detailed in this case series, STS appears to be an effective therapy for non-uremic calciphylaxis.
AB - Calciphylaxis is a metastatic calcification-induced vasculopathy that results in the occlusion of small blood vessels. Although calciphylaxis is normally associated with end-stage renal disease, calciphylaxis from non-uremic origin occurs as well. While the number of reports continues to increase, a standard treatment for non-uremic calciphylaxis has yet to be established. Sodium thiosulfate (STS), which has been proven to be effective in the treatment of uremic calciphylaxis, shows promise; however, reports of its use in non-uremic cases are limited. We describe a case of non-uremic calciphylaxis in a patient with normal renal and parathyroid function who had complete resolution of disease after treatment with STS, and we review similar cases in the published work. Based on the successful outcomes detailed in this case series, STS appears to be an effective therapy for non-uremic calciphylaxis.
KW - non-uremic calciphylaxis
KW - sodium thiosulfate
KW - uremic calciphylaxis
KW - vasculopathy
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U2 - 10.1111/1346-8138.12139
DO - 10.1111/1346-8138.12139
M3 - Article
C2 - 23663061
AN - SCOPUS:84881479380
SN - 0385-2407
VL - 40
SP - 649
EP - 652
JO - Journal of Dermatology
JF - Journal of Dermatology
IS - 8
ER -