Somatic Rearrangement in B Cells: It's (Mostly) Nuclear Physics

Erez Lieberman Aiden; Rafael Casellas

doi:10.1016/j.cell.2015.07.034

Somatic Rearrangement in B Cells: It's (Mostly) Nuclear Physics

Erez Lieberman Aiden, Rafael Casellas

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

We discuss how principles of nuclear architecture drive typical gene rearrangements in B lymphocytes, whereas translocation hot spots and recurrent lesions reflect the extent of AID-mediated DNA damage and selection.

Original language	English (US)
Pages (from-to)	708-711
Number of pages	4
Journal	Cell
Volume	162
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2015.07.034
State	Published - Aug 17 2015
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2015.07.034

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title = "Somatic Rearrangement in B Cells: It's (Mostly) Nuclear Physics",

abstract = "We discuss how principles of nuclear architecture drive typical gene rearrangements in B lymphocytes, whereas translocation hot spots and recurrent lesions reflect the extent of AID-mediated DNA damage and selection.",

author = "Aiden, {Erez Lieberman} and Rafael Casellas",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

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day = "17",

doi = "10.1016/j.cell.2015.07.034",

language = "English (US)",

volume = "162",

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T2 - It's (Mostly) Nuclear Physics

AU - Aiden, Erez Lieberman

AU - Casellas, Rafael

PY - 2015/8/17

Y1 - 2015/8/17

N2 - We discuss how principles of nuclear architecture drive typical gene rearrangements in B lymphocytes, whereas translocation hot spots and recurrent lesions reflect the extent of AID-mediated DNA damage and selection.

AB - We discuss how principles of nuclear architecture drive typical gene rearrangements in B lymphocytes, whereas translocation hot spots and recurrent lesions reflect the extent of AID-mediated DNA damage and selection.

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DO - 10.1016/j.cell.2015.07.034

M3 - Review article

C2 - 26276627

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SN - 0092-8674

VL - 162

SP - 708

EP - 711

JO - Cell

JF - Cell

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Somatic Rearrangement in B Cells: It's (Mostly) Nuclear Physics

Abstract

ASJC Scopus subject areas

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