Abstract
Human leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslational modifications or even complex formations. In addition, HLA-G has been described included in exosomes. In this review we will focus on HLA-G biochemistry with special emphasis to the mechanisms that regulate its expression and how the protein modifications affect the quantification in biological fluids.
Original language | English (US) |
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Article number | 657625 |
Journal | Journal of immunology research |
Volume | 2014 |
DOIs | |
State | Published - 2014 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology