Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in Müller Glial cell development

Ross A. Poché; Yasuhide Furuta; Marie Christine Chaboissier; Andreas Schedl; Richard R. Behringer

doi:10.1002/cne.21746

Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in Müller Glial cell development

Ross A. Poché, Yasuhide Furuta, Marie Christine Chaboissier, Andreas Schedl, Richard R. Behringer

Genetics

Research output: Contribution to journal › Article › peer-review

126 Scopus citations

Abstract

It is widely accepted that the process of retinal cell fate determination is under tight transcriptional control mediated by a combinatorial code of transcription factors. However, the exact repertoire of factors necessary for the genesis of each retinal cell type remains to be fully defined. Here we show that the HMG-box transcription factor, Sox9, is expressed in multipotent mouse retinal progenitor cells throughout retinogenesis. We also find that SOX9 is downregulated in differentiating neuronal populations, yet expression in Miller glial cells persists into adulthood. Furthermore, by employing a conditional knockout approach, we show that Sox9 is essential for the differentiation and/or survival of postnatal Miller glial cells.

Original language	English (US)
Pages (from-to)	237-250
Number of pages	14
Journal	Journal of Comparative Neurology
Volume	510
Issue number	3
DOIs	https://doi.org/10.1002/cne.21746
State	Published - Sep 20 2008

Keywords

Differentiation
Notch1
Retina
Sox2
Transcription factors

ASJC Scopus subject areas

General Neuroscience

MD Anderson CCSG core facilities

Advanced Technology Genomics Core

Access to Document

10.1002/cne.21746

Cite this

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AU - Behringer, Richard R.

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Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in Müller Glial cell development

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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