Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Tomer Illouz; Arya Biragyn; Milana Frenkel-Morgenstern; Orly Weissberg; Alessandro Gorohovski; Eugene Merzon; Ilan Green; Florencia Iulita; Lisi Flores-Aguilar; Mara Dierssen; Ilario De Toma; Hefziba Lifshitz; Stylianos E. Antonarakis; Eugene Yu; Yann Herault; Marie Claude Potier; Alexandra Botté; Randall Roper; Benjamin Sredni; Ronit Sarid; Jacqueline London; William Mobley; Andre Strydom; Eitan Okun

doi:10.1007/s12017-021-08651-5

Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Tomer Illouz, Arya Biragyn, Milana Frenkel-Morgenstern, Orly Weissberg, Alessandro Gorohovski, Eugene Merzon, Ilan Green, Florencia Iulita, Lisi Flores-Aguilar, Mara Dierssen, Ilario De Toma, Hefziba Lifshitz, Stylianos E. Antonarakis, Eugene Yu, Yann Herault, Marie Claude Potier, Alexandra Botté, Randall Roper, Benjamin Sredni, Ronit SaridJacqueline London, William Mobley, Andre Strydom, Eitan Okun

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. The incidence of Alzheimer’s disease (AD) is much higher in DS than in the general population, possibly increasing further the risk of COVID-19 infection and its complications. Here we provide a biological overview with regard to specific susceptibility of individuals with DS to SARS-CoV-2 infection as well as data from a recent survey on the prevalence of COVID-19 among them. We see an urgent need to protect people with DS, especially those with AD, from COVID-19 and future pandemics and focus on developing protective measures, which also include interventions by health systems worldwide for reducing the negative social effects of long-term isolation and increased periods of hospitalization.

Original language	English (US)
Pages (from-to)	561-571
Number of pages	11
Journal	NeuroMolecular Medicine
Volume	23
Issue number	4
DOIs	https://doi.org/10.1007/s12017-021-08651-5
State	Published - Dec 2021
Externally published	Yes

Keywords

COVID-19
Down syndrome
Immune dysregulation
SARS-CoV-2
Vaccine

ASJC Scopus subject areas

Molecular Medicine
Neurology
Cellular and Molecular Neuroscience

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Illouz, T., Biragyn, A., Frenkel-Morgenstern, M., Weissberg, O., Gorohovski, A., Merzon, E., Green, I., Iulita, F., Flores-Aguilar, L., Dierssen, M., De Toma, I., Lifshitz, H., Antonarakis, S. E., Yu, E., Herault, Y., Potier, M. C., Botté, A., Roper, R., Sredni, B., ... Okun, E. (2021). Specific Susceptibility to COVID-19 in Adults with Down Syndrome. NeuroMolecular Medicine, 23(4), 561-571. https://doi.org/10.1007/s12017-021-08651-5

Illouz, T, Biragyn, A, Frenkel-Morgenstern, M, Weissberg, O, Gorohovski, A, Merzon, E, Green, I, Iulita, F, Flores-Aguilar, L, Dierssen, M, De Toma, I, Lifshitz, H, Antonarakis, SE, Yu, E, Herault, Y, Potier, MC, Botté, A, Roper, R, Sredni, B, Sarid, R, London, J, Mobley, W, Strydom, A & Okun, E 2021, 'Specific Susceptibility to COVID-19 in Adults with Down Syndrome', NeuroMolecular Medicine, vol. 23, no. 4, pp. 561-571. https://doi.org/10.1007/s12017-021-08651-5

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abstract = "The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. The incidence of Alzheimer{\textquoteright}s disease (AD) is much higher in DS than in the general population, possibly increasing further the risk of COVID-19 infection and its complications. Here we provide a biological overview with regard to specific susceptibility of individuals with DS to SARS-CoV-2 infection as well as data from a recent survey on the prevalence of COVID-19 among them. We see an urgent need to protect people with DS, especially those with AD, from COVID-19 and future pandemics and focus on developing protective measures, which also include interventions by health systems worldwide for reducing the negative social effects of long-term isolation and increased periods of hospitalization.",

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AU - Yu, Eugene

AU - Herault, Yann

AU - Potier, Marie Claude

AU - Botté, Alexandra

AU - Roper, Randall

AU - Sredni, Benjamin

AU - Sarid, Ronit

AU - London, Jacqueline

AU - Mobley, William

AU - Strydom, Andre

AU - Okun, Eitan

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Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Abstract

Keywords

ASJC Scopus subject areas

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