Specificity of aversive stimulus properties of vasopressin

Rose Marie Bluthé; Robert Dantzer; Pierre Mormède; Michel Le Moal

doi:10.1007/BF00431815

Specificity of aversive stimulus properties of vasopressin

Rose Marie Bluthé, Robert Dantzer, Pierre Mormède, Michel Le Moal

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Rats injected SC with arginine vasopressin (AVP) following consumption of a milk solution developed a marked aversion to the taste of this solution. An analog of vasopressin devoid of pressor activity, dDAVP, was unable to induce conditioned taste aversion. The aversive stimulus properties of AVP were blocked by the vasopressor antagonist dPTyr(Me)AVP. This antagonist did not block apomorphine-mediated conditioned taste aversion. These results demonstrate that AVP induces conditioned taste aversion by interacting with vasopressor-like receptors.

Original language	English (US)
Pages (from-to)	238-241
Number of pages	4
Journal	Psychopharmacology
Volume	87
Issue number	2
DOIs	https://doi.org/10.1007/BF00431815
State	Published - Oct 1985
Externally published	Yes

Keywords

Apomorphine
Conditioned taste aversion
Hypertension
Rat
Vasopressin
Vasopressin analogs
Vasopressin antagonist

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00431815

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title = "Specificity of aversive stimulus properties of vasopressin",

abstract = "Rats injected SC with arginine vasopressin (AVP) following consumption of a milk solution developed a marked aversion to the taste of this solution. An analog of vasopressin devoid of pressor activity, dDAVP, was unable to induce conditioned taste aversion. The aversive stimulus properties of AVP were blocked by the vasopressor antagonist dPTyr(Me)AVP. This antagonist did not block apomorphine-mediated conditioned taste aversion. These results demonstrate that AVP induces conditioned taste aversion by interacting with vasopressor-like receptors.",

keywords = "Apomorphine, Conditioned taste aversion, Hypertension, Rat, Vasopressin, Vasopressin analogs, Vasopressin antagonist",

author = "Bluth{\'e}, {Rose Marie} and Robert Dantzer and Pierre Morm{\`e}de and {Le Moal}, Michel",

year = "1985",

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doi = "10.1007/BF00431815",

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pages = "238--241",

journal = "Psychopharmacology",

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T1 - Specificity of aversive stimulus properties of vasopressin

AU - Bluthé, Rose Marie

AU - Dantzer, Robert

AU - Mormède, Pierre

AU - Le Moal, Michel

PY - 1985/10

Y1 - 1985/10

N2 - Rats injected SC with arginine vasopressin (AVP) following consumption of a milk solution developed a marked aversion to the taste of this solution. An analog of vasopressin devoid of pressor activity, dDAVP, was unable to induce conditioned taste aversion. The aversive stimulus properties of AVP were blocked by the vasopressor antagonist dPTyr(Me)AVP. This antagonist did not block apomorphine-mediated conditioned taste aversion. These results demonstrate that AVP induces conditioned taste aversion by interacting with vasopressor-like receptors.

AB - Rats injected SC with arginine vasopressin (AVP) following consumption of a milk solution developed a marked aversion to the taste of this solution. An analog of vasopressin devoid of pressor activity, dDAVP, was unable to induce conditioned taste aversion. The aversive stimulus properties of AVP were blocked by the vasopressor antagonist dPTyr(Me)AVP. This antagonist did not block apomorphine-mediated conditioned taste aversion. These results demonstrate that AVP induces conditioned taste aversion by interacting with vasopressor-like receptors.

KW - Apomorphine

KW - Conditioned taste aversion

KW - Hypertension

KW - Rat

KW - Vasopressin

KW - Vasopressin analogs

KW - Vasopressin antagonist

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JO - Psychopharmacology

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ER -

Specificity of aversive stimulus properties of vasopressin

Abstract

Keywords

ASJC Scopus subject areas

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