Spinal injection of IL-2 or IL-15 alters mechanical and thermal withdrawal thresholds in rats

Juan P. Cata; Han Rong Weng; Patrick M. Dougherty

doi:10.1016/j.neulet.2008.03.074

Spinal injection of IL-2 or IL-15 alters mechanical and thermal withdrawal thresholds in rats

Juan P. Cata, Han Rong Weng, Patrick M. Dougherty

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

IL-2 and IL-15 were tested for effects on responses to mechanical or thermal stimuli when spinally administered to male Sprague-Dawley rats with surgically implanted intrathecal catheters. Restricted doses of both IL-2 and IL-15 produced increased responsiveness to mechanical stimulation of the hindpaws. This effect lasted up to 48 h. IL-2 had biphasic effects on thermal responses whereas IL-15 produced thermal hypalgesia alone. These effects dissipated within 24 h. These results suggest that IL-2 and IL-15 may participate in the generation of hyperalgesia in some pain conditions.

Original language	English (US)
Pages (from-to)	45-49
Number of pages	5
Journal	Neuroscience Letters
Volume	437
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2008.03.074
State	Published - May 23 2008

Keywords

Cytokines
Hypalgesia
Hyperalgesia

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2008.03.074

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title = "Spinal injection of IL-2 or IL-15 alters mechanical and thermal withdrawal thresholds in rats",

abstract = "IL-2 and IL-15 were tested for effects on responses to mechanical or thermal stimuli when spinally administered to male Sprague-Dawley rats with surgically implanted intrathecal catheters. Restricted doses of both IL-2 and IL-15 produced increased responsiveness to mechanical stimulation of the hindpaws. This effect lasted up to 48 h. IL-2 had biphasic effects on thermal responses whereas IL-15 produced thermal hypalgesia alone. These effects dissipated within 24 h. These results suggest that IL-2 and IL-15 may participate in the generation of hyperalgesia in some pain conditions.",

keywords = "Cytokines, Hypalgesia, Hyperalgesia",

author = "Cata, {Juan P.} and Weng, {Han Rong} and Dougherty, {Patrick M.}",

note = "Funding Information: This work was supported by NIH Grants CA-39933 and NS-109624.",

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T1 - Spinal injection of IL-2 or IL-15 alters mechanical and thermal withdrawal thresholds in rats

AU - Cata, Juan P.

AU - Weng, Han Rong

AU - Dougherty, Patrick M.

N1 - Funding Information: This work was supported by NIH Grants CA-39933 and NS-109624.

PY - 2008/5/23

Y1 - 2008/5/23

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AB - IL-2 and IL-15 were tested for effects on responses to mechanical or thermal stimuli when spinally administered to male Sprague-Dawley rats with surgically implanted intrathecal catheters. Restricted doses of both IL-2 and IL-15 produced increased responsiveness to mechanical stimulation of the hindpaws. This effect lasted up to 48 h. IL-2 had biphasic effects on thermal responses whereas IL-15 produced thermal hypalgesia alone. These effects dissipated within 24 h. These results suggest that IL-2 and IL-15 may participate in the generation of hyperalgesia in some pain conditions.

KW - Cytokines

KW - Hypalgesia

KW - Hyperalgesia

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Spinal injection of IL-2 or IL-15 alters mechanical and thermal withdrawal thresholds in rats

Abstract

Keywords

ASJC Scopus subject areas

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