Squamous metaplasia of the canaliculi associated with 5-fluorouracil: A clinicopathologic case report

Madhu R. Agarwal; Bita Esmaeli; Michael A. Burnstine

doi:10.1016/S0161-6420(02)01290-3

Squamous metaplasia of the canaliculi associated with 5-fluorouracil: A clinicopathologic case report

Madhu R. Agarwal, Bita Esmaeli, Michael A. Burnstine

Plastic Surgery

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Objective: To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer. Design: Interventional case report. Methods: A full-thickness section of canaliculus was obtained during surgical repair. Main Outcome Measure: Histopathologic changes in the specimen. Results: The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen. Conclusion: Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.

Original language	English (US)
Pages (from-to)	2359-2361
Number of pages	3
Journal	Ophthalmology
Volume	109
Issue number	12
DOIs	https://doi.org/10.1016/S0161-6420(02)01290-3
State	Published - Dec 1 2002

ASJC Scopus subject areas

Ophthalmology

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10.1016/S0161-6420(02)01290-3

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title = "Squamous metaplasia of the canaliculi associated with 5-fluorouracil: A clinicopathologic case report",

abstract = "Objective: To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer. Design: Interventional case report. Methods: A full-thickness section of canaliculus was obtained during surgical repair. Main Outcome Measure: Histopathologic changes in the specimen. Results: The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen. Conclusion: Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.",

author = "Agarwal, {Madhu R.} and Bita Esmaeli and Burnstine, {Michael A.}",

note = "Funding Information: Supported in part by core grant no. EY03040 from the National Institutes of Health, Bethesda, Maryland, and an unrestricted grant from Research to Prevent Blindness, New York, New York. ",

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doi = "10.1016/S0161-6420(02)01290-3",

language = "English (US)",

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T1 - Squamous metaplasia of the canaliculi associated with 5-fluorouracil

T2 - A clinicopathologic case report

AU - Agarwal, Madhu R.

AU - Esmaeli, Bita

AU - Burnstine, Michael A.

N1 - Funding Information: Supported in part by core grant no. EY03040 from the National Institutes of Health, Bethesda, Maryland, and an unrestricted grant from Research to Prevent Blindness, New York, New York.

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Objective: To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer. Design: Interventional case report. Methods: A full-thickness section of canaliculus was obtained during surgical repair. Main Outcome Measure: Histopathologic changes in the specimen. Results: The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen. Conclusion: Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.

AB - Objective: To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer. Design: Interventional case report. Methods: A full-thickness section of canaliculus was obtained during surgical repair. Main Outcome Measure: Histopathologic changes in the specimen. Results: The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen. Conclusion: Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.

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Squamous metaplasia of the canaliculi associated with 5-fluorouracil: A clinicopathologic case report

Abstract

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